The evaluation of low dose pre‐operative X‐ray therapy in the management of operable rectal cancer; results of a randomly controlled trial

W. Duncan; A. N. Smith; L. S. Freedman; M. R. Alderson; S. J. Arnott; N. M. Bleehen; W. H. Bond; D. Crowther; T. J. Deeley; H. L. Duthie; P. W. Dykes; L. P. Fielding; G. E. Flatman; J. C. Goligher; P. R. Hawley; L. E. Hughes; C. A.F. Joslin; O. M. Koriech; B. C. Morson; G. D. Oates; M. J. Peckham; M. R. Sandland; P. F. Schofield; W. Slack; G. Slaney; J. A.R. Smith; J. Stewart Scott; J. M.A. Whitehouse; P. F.M. Wrigley; A. York‐Mason

doi:10.1002/bjs.1800710107

The evaluation of low dose pre‐operative X‐ray therapy in the management of operable rectal cancer; results of a randomly controlled trial

W. Duncan
, A. N. Smith
, L. S. Freedman
, M. R. Alderson
, S. J. Arnott
, N. M. Bleehen
, W. H. Bond
, D. Crowther
, T. J. Deeley
, H. L. Duthie
, P. W. Dykes
, L. P. Fielding
, G. E. Flatman
, J. C. Goligher
, P. R. Hawley
, L. E. Hughes
, C. A.F. Joslin
, O. M. Koriech
, B. C. Morson
, G. D. Oates

M. J. Peckham, M. R. Sandland, P. F. Schofield, W. Slack, G. Slaney, J. A.R. Smith, J. Stewart Scott, J. M.A. Whitehouse, P. F.M. Wrigley, A. York‐Mason

NHS Lothian

Research output: Contribution to journal › Article › peer-review

202 Scopus citations

Abstract

824 patients with operable rectal carcinoma were randomly allocated to be treated by surgery alone, 2000 rad in 10 daily fractions and 500 rad as a single fraction. No difference has been demonstrated in the actuarial survival rates to 5 years. The local recurrence‐free and metastasis‐free rates are similar in all groups. There is also no evidence that the pre‐operative radiotherapy benefited patients in subgroups by Dukes' stage. The complication rates were also similar in the three treatment groups.

Original language	English
Pages (from-to)	21-25
Number of pages	5
Journal	British Journal of Surgery
Volume	71
Issue number	1
DOIs	https://doi.org/10.1002/bjs.1800710107
State	Published - Jan 1984
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adjuvant X‐ray therapy
complication rates
pre‐operative treatment
rectal cancer
survival rates

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10.1002/bjs.1800710107

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Duncan, W., Smith, A. N., Freedman, L. S., Alderson, M. R., Arnott, S. J., Bleehen, N. M., Bond, W. H., Crowther, D., Deeley, T. J., Duthie, H. L., Dykes, P. W., Fielding, L. P., Flatman, G. E., Goligher, J. C., Hawley, P. R., Hughes, L. E., Joslin, C. A. F., Koriech, O. M., Morson, B. C., ... York‐Mason, A. (1984). The evaluation of low dose pre‐operative X‐ray therapy in the management of operable rectal cancer; results of a randomly controlled trial. British Journal of Surgery, 71(1), 21-25. https://doi.org/10.1002/bjs.1800710107

@article{505ee8f981fa42fea2e49135b853ca74,

title = "The evaluation of low dose pre‐operative X‐ray therapy in the management of operable rectal cancer; results of a randomly controlled trial",

abstract = "824 patients with operable rectal carcinoma were randomly allocated to be treated by surgery alone, 2000 rad in 10 daily fractions and 500 rad as a single fraction. No difference has been demonstrated in the actuarial survival rates to 5 years. The local recurrence‐free and metastasis‐free rates are similar in all groups. There is also no evidence that the pre‐operative radiotherapy benefited patients in subgroups by Dukes' stage. The complication rates were also similar in the three treatment groups.",

keywords = "Adjuvant X‐ray therapy, complication rates, pre‐operative treatment, rectal cancer, survival rates",

author = "W. Duncan and Smith, \{A. N.\} and Freedman, \{L. S.\} and Alderson, \{M. R.\} and Arnott, \{S. J.\} and Bleehen, \{N. M.\} and Bond, \{W. H.\} and D. Crowther and Deeley, \{T. J.\} and Duthie, \{H. L.\} and Dykes, \{P. W.\} and Fielding, \{L. P.\} and Flatman, \{G. E.\} and Goligher, \{J. C.\} and Hawley, \{P. R.\} and Hughes, \{L. E.\} and Joslin, \{C. A.F.\} and Koriech, \{O. M.\} and Morson, \{B. C.\} and Oates, \{G. D.\} and Peckham, \{M. J.\} and Sandland, \{M. R.\} and Schofield, \{P. F.\} and W. Slack and G. Slaney and Smith, \{J. A.R.\} and Scott, \{J. Stewart\} and Whitehouse, \{J. M.A.\} and Wrigley, \{P. F.M.\} and A. York‐Mason",

year = "1984",

month = jan,

doi = "10.1002/bjs.1800710107",

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Duncan, W, Smith, AN, Freedman, LS, Alderson, MR, Arnott, SJ, Bleehen, NM, Bond, WH, Crowther, D, Deeley, TJ, Duthie, HL, Dykes, PW, Fielding, LP, Flatman, GE, Goligher, JC, Hawley, PR, Hughes, LE, Joslin, CAF, Koriech, OM, Morson, BC, Oates, GD, Peckham, MJ, Sandland, MR, Schofield, PF, Slack, W, Slaney, G, Smith, JAR, Scott, JS, Whitehouse, JMA, Wrigley, PFM & York‐Mason, A 1984, 'The evaluation of low dose pre‐operative X‐ray therapy in the management of operable rectal cancer; results of a randomly controlled trial', British Journal of Surgery, vol. 71, no. 1, pp. 21-25. https://doi.org/10.1002/bjs.1800710107

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T1 - The evaluation of low dose pre‐operative X‐ray therapy in the management of operable rectal cancer; results of a randomly controlled trial

AU - Duncan, W.

AU - Smith, A. N.

AU - Freedman, L. S.

AU - Alderson, M. R.

AU - Arnott, S. J.

AU - Bleehen, N. M.

AU - Bond, W. H.

AU - Crowther, D.

AU - Deeley, T. J.

AU - Duthie, H. L.

AU - Dykes, P. W.

AU - Fielding, L. P.

AU - Flatman, G. E.

AU - Goligher, J. C.

AU - Hawley, P. R.

AU - Hughes, L. E.

AU - Joslin, C. A.F.

AU - Koriech, O. M.

AU - Morson, B. C.

AU - Oates, G. D.

AU - Peckham, M. J.

AU - Sandland, M. R.

AU - Schofield, P. F.

AU - Slack, W.

AU - Slaney, G.

AU - Smith, J. A.R.

AU - Scott, J. Stewart

AU - Whitehouse, J. M.A.

AU - Wrigley, P. F.M.

AU - York‐Mason, A.

PY - 1984/1

Y1 - 1984/1

N2 - 824 patients with operable rectal carcinoma were randomly allocated to be treated by surgery alone, 2000 rad in 10 daily fractions and 500 rad as a single fraction. No difference has been demonstrated in the actuarial survival rates to 5 years. The local recurrence‐free and metastasis‐free rates are similar in all groups. There is also no evidence that the pre‐operative radiotherapy benefited patients in subgroups by Dukes' stage. The complication rates were also similar in the three treatment groups.

AB - 824 patients with operable rectal carcinoma were randomly allocated to be treated by surgery alone, 2000 rad in 10 daily fractions and 500 rad as a single fraction. No difference has been demonstrated in the actuarial survival rates to 5 years. The local recurrence‐free and metastasis‐free rates are similar in all groups. There is also no evidence that the pre‐operative radiotherapy benefited patients in subgroups by Dukes' stage. The complication rates were also similar in the three treatment groups.

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KW - complication rates

KW - pre‐operative treatment

KW - rectal cancer

KW - survival rates

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JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 1

ER -

The evaluation of low dose pre‐operative X‐ray therapy in the management of operable rectal cancer; results of a randomly controlled trial

Abstract

UN SDGs

Keywords

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