The evaluation of low dose pre‐operative X‐ray therapy in the management of operable rectal cancer; results of a randomly controlled trial

W. Duncan, A. N. Smith, L. S. Freedman, M. R. Alderson, S. J. Arnott, N. M. Bleehen, W. H. Bond, D. Crowther, T. J. Deeley, H. L. Duthie, P. W. Dykes, L. P. Fielding, G. E. Flatman, J. C. Goligher, P. R. Hawley, L. E. Hughes, C. A.F. Joslin, O. M. Koriech, B. C. Morson, G. D. OatesM. J. Peckham, M. R. Sandland, P. F. Schofield, W. Slack, G. Slaney, J. A.R. Smith, J. Stewart Scott, J. M.A. Whitehouse, P. F.M. Wrigley, A. York‐Mason

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Abstract

824 patients with operable rectal carcinoma were randomly allocated to be treated by surgery alone, 2000 rad in 10 daily fractions and 500 rad as a single fraction. No difference has been demonstrated in the actuarial survival rates to 5 years. The local recurrence‐free and metastasis‐free rates are similar in all groups. There is also no evidence that the pre‐operative radiotherapy benefited patients in subgroups by Dukes' stage. The complication rates were also similar in the three treatment groups.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalBritish Journal of Surgery
Volume71
Issue number1
DOIs
StatePublished - Jan 1984
Externally publishedYes

Keywords

  • Adjuvant X‐ray therapy
  • complication rates
  • pre‐operative treatment
  • rectal cancer
  • survival rates

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