TY - JOUR
T1 - The effects of risperidone vs haloperidol on cognitive functioning in treatment-resistant schizophrenia
T2 - The trail making test
AU - Mcgurk, Susan R.
AU - Green, Michael F.
AU - Wirshing, William C.
AU - Ames, Donna
AU - Marshall, B. D.
AU - Marder, Steven R.
AU - Mintz, Jim
PY - 1997
Y1 - 1997
N2 - In this article, data are presented from Parts A and B of the Trail Making Test, which examined the effects of haloperidol vs risperidone on cognitive function in treatment-resistant scxhizophrenic patients. This report focuses on findings from the Trail Making Test. Overall, risperidone had a positive effect on Trail Making Part B performance following 4 weeks of treatment. These effects were due, at least in part, to the direct effects of risperidone. The possibility that an antipsychotic agent can enhance executive functioning through direct mechanisms, perhaps mediated by frontal cortex neurochemistry, indicates that the evaluation of antipsychotic medications in the treatment of schizophrenia should be expanded to include cognition.
AB - In this article, data are presented from Parts A and B of the Trail Making Test, which examined the effects of haloperidol vs risperidone on cognitive function in treatment-resistant scxhizophrenic patients. This report focuses on findings from the Trail Making Test. Overall, risperidone had a positive effect on Trail Making Part B performance following 4 weeks of treatment. These effects were due, at least in part, to the direct effects of risperidone. The possibility that an antipsychotic agent can enhance executive functioning through direct mechanisms, perhaps mediated by frontal cortex neurochemistry, indicates that the evaluation of antipsychotic medications in the treatment of schizophrenia should be expanded to include cognition.
UR - http://www.scopus.com/inward/record.url?scp=0002826116&partnerID=8YFLogxK
U2 - 10.1017/s1092852900005058
DO - 10.1017/s1092852900005058
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AN - SCOPUS:0002826116
SN - 1092-8529
VL - 2
SP - 60
EP - 64
JO - CNS Spectrums
JF - CNS Spectrums
IS - 8
ER -
