Abstract
The neuropharmacological basis for d-amphetamine induced paradoxical behavioral thermoregulation remains unclear. This study examined thermoregulatory behavior of rats in a runway device that housed a heat source at one end and in which locomotion along the length of the runway could be observed. Sprague Dawley rats were pretreated with IP injections of saline, β-endorphin, MIF-I, or α-MSH, with a repeat injection after 30 min. In a second experiment, d-amphetamine was administered as the repeat drug for all Ss. The results showed clear differences for heat-source-on vs. heat-source off. All peptides induced hypermotility, although no differentiated effects for the peptides on d-amphetamine induced paradoxical behavioral thermoregulation were found. These findings are discussed in light of the theoretical possibilities that: (a) a ceiling effect exists; (b) there are separate control systems for maintaining body temperature and another for behavioral thermoregulatory responses, and (c) other neurotransmitters may be involved in such induced paradoxical behavioral thermoregulation.
| Original language | English |
|---|---|
| Pages (from-to) | 189-192 |
| Number of pages | 4 |
| Journal | Peptides |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1985 |
Bibliographical note
Funding Information:d-Amphetamine sulfate was generously donated by Smith, Kline and French. The work was supported by a grant from the Research Authority, Bar-Ilan University.
Keywords
- Dopamine
- MIF-I
- Motor activity
- Paradoxical behavioral thermoregulation
- d-Amphetamine
- α-MSH
- β-Endorphin