The effects of metal implants on inflammatory and healing processes

Roman Tsaryk, Kirsten Peters, Ronald E. Unger, Dieter Scharnweber, C. James Kirkpatrick

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Metal implants are known for their superior mechanical properties. However, cases of implant failure mainly due to aseptic loosening do occur. The formation of particulate wear debris and corrosion products, such as metal ions and reactive oxygen species, are considered to be crucial factors leading to the failure of metal implants. These metal degradation and corrosion products can induce inflammatory responses, mediated among others by neutrophils, macrophages and endothelial cells. Furthermore, these degradation products may affect blood vessel formation, one of the central processes in wound healing after implantation. Such events can lead to the aseptic loosening of implants culminating in the necessity for revision surgery.

Original languageEnglish
Pages (from-to)622-629
Number of pages8
JournalInternational Journal of Materials Research
Issue number7
StatePublished - Jul 2007
Externally publishedYes


  • Inflammation
  • Metal ions
  • Metal particles
  • Reactive oxygen species
  • Wound healing


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