Abstract
The effects of Delta-Sleep-Induced Peptide (DSIP) were examined in rats kept at 12:12 light:dark schedule. The peak of the circadian pain threshold of saline-treated rats occurred at 10:00. Rats treated with 0.1 mg/kg, i.p. DSIP exhibited a significantly higher pain threshold level (as measured by hot plate) both in the light and dark periods. Prior to the treatment the peak was at 10:00. With treatment the peak shifted to 18:00. A dose of 1.0 mg/kg DSIP increased the pain threshold level only during the dark period. The analgesia induced by DSIP is insensitive to naloxone pretreatment.
| Original language | English |
|---|---|
| Pages (from-to) | 85-88 |
| Number of pages | 4 |
| Journal | International Journal of Neuroscience |
| Volume | 37 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Nov 1987 |
Bibliographical note
Funding Information:This research was partially supported by the Keasearch Authority of Bar-Ilan University. Thanks are due to Elisabeth Sherwin for her help in all phases of this paper.
Funding
This research was partially supported by the Keasearch Authority of Bar-Ilan University. Thanks are due to Elisabeth Sherwin for her help in all phases of this paper.
| Funders |
|---|
| Keasearch Authority of Bar-Ilan University |
Keywords
- Circadian cycle
- DSIP
- Naloxone
- Pain threshold
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