The effects of dsip on pain threshold during light and dark periods in rats are not naloxone-sensitive

Shlomo Yehuda, Ralph L. Carasso

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The effects of Delta-Sleep-Induced Peptide (DSIP) were examined in rats kept at 12:12 light:dark schedule. The peak of the circadian pain threshold of saline-treated rats occurred at 10:00. Rats treated with 0.1 mg/kg, i.p. DSIP exhibited a significantly higher pain threshold level (as measured by hot plate) both in the light and dark periods. Prior to the treatment the peak was at 10:00. With treatment the peak shifted to 18:00. A dose of 1.0 mg/kg DSIP increased the pain threshold level only during the dark period. The analgesia induced by DSIP is insensitive to naloxone pretreatment.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalInternational Journal of Neuroscience
Volume37
Issue number1-2
DOIs
StatePublished - Nov 1987

Bibliographical note

Funding Information:
This research was partially supported by the Keasearch Authority of Bar-Ilan University. Thanks are due to Elisabeth Sherwin for her help in all phases of this paper.

Funding

This research was partially supported by the Keasearch Authority of Bar-Ilan University. Thanks are due to Elisabeth Sherwin for her help in all phases of this paper.

FundersFunder number
Keasearch Authority of Bar-Ilan University

    Keywords

    • Circadian cycle
    • DSIP
    • Naloxone
    • Pain threshold

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