Abstract
The effects of D-amphetamine on the colonic temperature of the rat vary markedly with the ambient temperature. At fixed relative humidities, D-amphetamine causes a dose-dependent hyperthermia among animals placed in warm environments (20-37°C), and hypothermia among rats placed in the cold (4-15°C). The changes in colonic temperature that follow the administration of chlorpromazine, reserpine, tyramine, fenfluramine, or pimozide also depend upon the ambient temperature. Since tyramine treatment mimics the hyperthermic, but not the hypothermic, effects of D-amphetamine, and since D-amphetamine-induced hypothermia is blocked by pimozide, this hypothermia may involve central dopaminergic neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 851-859 |
| Number of pages | 9 |
| Journal | Life Sciences |
| Volume | 11 |
| Issue number | 18 PART 1 |
| DOIs | |
| State | Published - 15 Sep 1972 |
| Externally published | Yes |
Bibliographical note
Funding Information:These studies were supported in part by grants from the United States Public Health Service (AM-11709 and AM-11237), and by a grant from the Alfred P . Sloan Foundation to M .I .T .
Funding
These studies were supported in part by grants from the United States Public Health Service (AM-11709 and AM-11237), and by a grant from the Alfred P . Sloan Foundation to M .I .T .
| Funders | Funder number |
|---|---|
| U.S. Public Health Service | AM-11709, AM-11237 |