The effects of D-amphetamine and related drugs on colonic temperatures of rats kept at various ambient temperatures

Shlomo Yehuda, Richard J. Wurtman

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84 Scopus citations

Abstract

The effects of D-amphetamine on the colonic temperature of the rat vary markedly with the ambient temperature. At fixed relative humidities, D-amphetamine causes a dose-dependent hyperthermia among animals placed in warm environments (20-37°C), and hypothermia among rats placed in the cold (4-15°C). The changes in colonic temperature that follow the administration of chlorpromazine, reserpine, tyramine, fenfluramine, or pimozide also depend upon the ambient temperature. Since tyramine treatment mimics the hyperthermic, but not the hypothermic, effects of D-amphetamine, and since D-amphetamine-induced hypothermia is blocked by pimozide, this hypothermia may involve central dopaminergic neurons.

Original languageEnglish
Pages (from-to)851-859
Number of pages9
JournalLife Sciences
Volume11
Issue number18 PART 1
DOIs
StatePublished - 15 Sep 1972
Externally publishedYes

Bibliographical note

Funding Information:
These studies were supported in part by grants from the United States Public Health Service (AM-11709 and AM-11237), and by a grant from the Alfred P . Sloan Foundation to M .I .T .

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