The effects of clozapine and risperidone on spatial working memory in schizophrenia

Susan R. McGurk; Cameron Carter; Robert Goldman; Michael F. Green; Stephen R. Marder; Haiyi Xie; Nina R. Schooler; John M. Kane

doi:10.1176/appi.ajp.162.5.1013

The effects of clozapine and risperidone on spatial working memory in schizophrenia

Susan R. McGurk
, Cameron Carter
, Robert Goldman
, Michael F. Green
, Stephen R. Marder
, Haiyi Xie
, Nina R. Schooler
, John M. Kane

Department of Computer Science and Artificial Intelligence

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Objective: The purpose of this investigation was to evaluate the effects of clozapine and risperidone on spatial working memory in patients with schizophrenia. Method: Spatial working memory performance was evaluated at baseline and after 17 and 29 weeks in 97 patients with schizophrenia participating in a multisite trial. Results: Compared with baseline performance while receiving conventional antipsychotic medication, risperidone improved, and clozapine worsened, spatial working memory performance. Conclusions: The differential effects of these medications on spatial working memory may be due to the anticholinergic effects of clozapine and prefrontal dopamine-enhancing effects of risperidone.

Original language	English
Pages (from-to)	1013-1016
Number of pages	4
Journal	American Journal of Psychiatry
Volume	162
Issue number	5
DOIs	https://doi.org/10.1176/appi.ajp.162.5.1013
State	Published - May 2005

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SDG 3 Good Health and Well-being

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10.1176/appi.ajp.162.5.1013

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title = "The effects of clozapine and risperidone on spatial working memory in schizophrenia",

abstract = "Objective: The purpose of this investigation was to evaluate the effects of clozapine and risperidone on spatial working memory in patients with schizophrenia. Method: Spatial working memory performance was evaluated at baseline and after 17 and 29 weeks in 97 patients with schizophrenia participating in a multisite trial. Results: Compared with baseline performance while receiving conventional antipsychotic medication, risperidone improved, and clozapine worsened, spatial working memory performance. Conclusions: The differential effects of these medications on spatial working memory may be due to the anticholinergic effects of clozapine and prefrontal dopamine-enhancing effects of risperidone.",

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AU - Xie, Haiyi

AU - Schooler, Nina R.

AU - Kane, John M.

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The effects of clozapine and risperidone on spatial working memory in schizophrenia

Abstract

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