The effects of clozapine and risperidone on spatial working memory in schizophrenia

Susan R. McGurk; Cameron Carter; Robert Goldman; Michael F. Green; Stephen R. Marder; Haiyi Xie; Nina R. Schooler; John M. Kane

doi:10.1176/appi.ajp.162.5.1013

The effects of clozapine and risperidone on spatial working memory in schizophrenia

Susan R. McGurk, Cameron Carter, Robert Goldman, Michael F. Green, Stephen R. Marder, Haiyi Xie, Nina R. Schooler, John M. Kane

Department of Computer Science

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Objective: The purpose of this investigation was to evaluate the effects of clozapine and risperidone on spatial working memory in patients with schizophrenia. Method: Spatial working memory performance was evaluated at baseline and after 17 and 29 weeks in 97 patients with schizophrenia participating in a multisite trial. Results: Compared with baseline performance while receiving conventional antipsychotic medication, risperidone improved, and clozapine worsened, spatial working memory performance. Conclusions: The differential effects of these medications on spatial working memory may be due to the anticholinergic effects of clozapine and prefrontal dopamine-enhancing effects of risperidone.

Original language	English
Pages (from-to)	1013-1016
Number of pages	4
Journal	American Journal of Psychiatry
Volume	162
Issue number	5
DOIs	https://doi.org/10.1176/appi.ajp.162.5.1013
State	Published - May 2005

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The effects of clozapine and risperidone on spatial working memory in schizophrenia

Abstract

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