The effects of age on the metabolic and electrical responses to decapitation in the awake and the anesthetized rat brain

Nili Zarchin; Avraham Mayevsky

doi:10.1016/0047-6374(81)90104-4

The effects of age on the metabolic and electrical responses to decapitation in the awake and the anesthetized rat brain

Nili Zarchin, Avraham Mayevsky

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The effects of age on the responses of the brain to decapitation (complete ischemia) were tested in the awake and anesthesized rat. The metabolic and reflected light activities were evaluated by the use of a DC fluorometer/reflectometer (one or two hemispheres) and the electrical activity was measured by electrocortigram. In all 81 animals used in these experiments the above-mentioned parameters were measured, to enable comparison between the age groups. The rats were divided into six age groups ranging from 2 to 120 weeks and each age group was subdivided into awake and anesthetized animals. The results can be summarized as follows. (1) The rate of energy consumption was lower in the young (2 weeks) and the old rats (120 weeks) compared to the adults rats. (2) The effect of anesthetic was more pronounced in the young and the old rats than in the adult rats. (3) The electrical activity was in good correlation with the energy availability in all animals of various ages as well as in the awake and anesthetized rats.

Original language	English
Pages (from-to)	285-294
Number of pages	10
Journal	Mechanisms of Ageing and Development
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/0047-6374(81)90104-4
State	Published - Jul 1981

Bibliographical note

Funding Information:
This work was supported by a grant from the United States-Israel Binational Sciences Foundation (BSF), Jerusalem, Israel, by a portion of the Program Project Grant NS 10939, and by a grant from the Brookdale-Bar-Ilan Program for Applied Gerontology at Bar-Ilan University.

Funding

This work was supported by a grant from the United States-Israel Binational Sciences Foundation (BSF), Jerusalem, Israel, by a portion of the Program Project Grant NS 10939, and by a grant from the Brookdale-Bar-Ilan Program for Applied Gerontology at Bar-Ilan University.

Funders	Funder number
Brookdale-Bar-Ilan Program for Applied Gerontology
National Institute of Neurological Disorders and Stroke	P50NS010939
United States-Israel Binational Science Foundation

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10.1016/0047-6374(81)90104-4

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title = "The effects of age on the metabolic and electrical responses to decapitation in the awake and the anesthetized rat brain",

abstract = "The effects of age on the responses of the brain to decapitation (complete ischemia) were tested in the awake and anesthesized rat. The metabolic and reflected light activities were evaluated by the use of a DC fluorometer/reflectometer (one or two hemispheres) and the electrical activity was measured by electrocortigram. In all 81 animals used in these experiments the above-mentioned parameters were measured, to enable comparison between the age groups. The rats were divided into six age groups ranging from 2 to 120 weeks and each age group was subdivided into awake and anesthetized animals. The results can be summarized as follows. (1) The rate of energy consumption was lower in the young (2 weeks) and the old rats (120 weeks) compared to the adults rats. (2) The effect of anesthetic was more pronounced in the young and the old rats than in the adult rats. (3) The electrical activity was in good correlation with the energy availability in all animals of various ages as well as in the awake and anesthetized rats.",

author = "Nili Zarchin and Avraham Mayevsky",

note = "Funding Information: This work was supported by a grant from the United States-Israel Binational Sciences Foundation (BSF), Jerusalem, Israel, by a portion of the Program Project Grant NS 10939, and by a grant from the Brookdale-Bar-Ilan Program for Applied Gerontology at Bar-Ilan University.",

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AU - Mayevsky, Avraham

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The effects of age on the metabolic and electrical responses to decapitation in the awake and the anesthetized rat brain

Abstract

Bibliographical note

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