The effect of trimethadione on brain energy metabolism and EEG activity of the conscious rat exposed to HPO

Avraham Mayevsky

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation‐reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calculated. The results show that in TMO‐treated animals the time to the onset of convulsions, the time to the onset of NADH oxidation‐reduction cycles, and the survival time were significantly longer than in the control group. The effect of TMO on the EEG shows that the tonic phase of the convulsive activity was almost completely abolished.

Original languageEnglish
Pages (from-to)131-142
Number of pages12
JournalJournal of Neuroscience Research
Volume1
Issue number2
DOIs
StatePublished - 1975
Externally publishedYes

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