TY - JOUR
T1 - The effect of trimethadione on brain energy metabolism and EEG activity of the conscious rat exposed to HPO
AU - Mayevsky, Avraham
PY - 1975
Y1 - 1975
N2 - The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation‐reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calculated. The results show that in TMO‐treated animals the time to the onset of convulsions, the time to the onset of NADH oxidation‐reduction cycles, and the survival time were significantly longer than in the control group. The effect of TMO on the EEG shows that the tonic phase of the convulsive activity was almost completely abolished.
AB - The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation‐reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calculated. The results show that in TMO‐treated animals the time to the onset of convulsions, the time to the onset of NADH oxidation‐reduction cycles, and the survival time were significantly longer than in the control group. The effect of TMO on the EEG shows that the tonic phase of the convulsive activity was almost completely abolished.
UR - http://www.scopus.com/inward/record.url?scp=0016804947&partnerID=8YFLogxK
U2 - 10.1002/jnr.490010205
DO - 10.1002/jnr.490010205
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C2 - 177790
AN - SCOPUS:0016804947
SN - 0360-4012
VL - 1
SP - 131
EP - 142
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
IS - 2
ER -