The effect of pain on pentylenetetrazol induced seizures

Shlomo Yehuda; Raphael L. Carasso; David I. Mostofsky

doi:10.3109/00207459108990742

The effect of pain on pentylenetetrazol induced seizures

Shlomo Yehuda, Raphael L. Carasso, David I. Mostofsky

Department of Psychology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Repeated administrations of subconvulsive doses of pentylenetetrazol (PTZ) leads to frank convulsions. The number of injections required to bring about such an effect is taken as an index of seizure vulnerability, and was studied in normal rats. This study examined the effect of pain induced by formaline injection or placement on a hot plate on seizure elicitation. The results could be accounted for by the role of arousal and/or endogenous opiates that are generated by the pain induction procedures, wherein the pain appears to provide some elevation of the threshold for seizure vulnerability.

Original language	English
Pages (from-to)	255-258
Number of pages	4
Journal	International Journal of Neuroscience
Volume	61
Issue number	3-4
DOIs	https://doi.org/10.3109/00207459108990742
State	Published - Dec 1991

Keywords

Pain
Pentylenetetrazol
Seizures

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AB - Repeated administrations of subconvulsive doses of pentylenetetrazol (PTZ) leads to frank convulsions. The number of injections required to bring about such an effect is taken as an index of seizure vulnerability, and was studied in normal rats. This study examined the effect of pain induced by formaline injection or placement on a hot plate on seizure elicitation. The results could be accounted for by the role of arousal and/or endogenous opiates that are generated by the pain induction procedures, wherein the pain appears to provide some elevation of the threshold for seizure vulnerability.

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The effect of pain on pentylenetetrazol induced seizures

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Keywords

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