The effect of nanoparticle size on theranostic systems: The optimal particle size for imaging is not necessarily optimal for drug delivery

Tamar Dreifuss; Oshra Betzer; Eran Barnoy; Menachem Motiei; Rachela Popovtzer

doi:10.1117/12.2287392

The effect of nanoparticle size on theranostic systems: The optimal particle size for imaging is not necessarily optimal for drug delivery

Tamar Dreifuss, Oshra Betzer, Eran Barnoy, Menachem Motiei, Rachela Popovtzer

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Theranostics is an emerging field, defined as combination of therapeutic and diagnostic capabilities in the same material. Nanoparticles are considered as an efficient platform for theranostics, particularly in cancer treatment, as they offer substantial advantages over both common imaging contrast agents and chemotherapeutic drugs. However, the development of theranostic nanoplatforms raises an important question: Is the optimal particle for imaging also optimal for therapy? Are the specific parameters required for maximal drug delivery, similar to those required for imaging applications? Herein, we examined this issue by investigating the effect of nanoparticle size on tumor uptake and imaging. Anti-epidermal growth factor receptor (EGFR)-conjugated gold nanoparticles (GNPs) in different sizes (diameter range: 20-120 nm) were injected to tumor bearing mice and their uptake by tumors was measured, as well as their tumor visualization capabilities as tumor-targeted CT contrast agent. Interestingly, the results showed that different particles led to highest tumor uptake or highest contrast enhancement, meaning that the optimal particle size for drug delivery is not necessarily optimal for tumor imaging. These results have important implications on the design of theranostic nanoplatforms.

Original language	English
Title of host publication	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV
Editors	Dan V. Nicolau, Alexander N. Cartwright, Dror Fixler
Publisher	SPIE
ISBN (Electronic)	9781510614970
DOIs	https://doi.org/10.1117/12.2287392
State	Published - 2018
Event	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV 2018 - San Francisco, United States Duration: 30 Jan 2018 → 31 Jan 2018

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10506
ISSN (Print)	1605-7422

Conference

Conference	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV 2018
Country/Territory	United States
City	San Francisco
Period	30/01/18 → 31/01/18

Bibliographical note

Publisher Copyright:
© 2018 SPIE.

Funding

This work was partially supported by the Israel Cancer Research Fund (ICRF), by the Israel Science Foundation (grant # 749/14), by the Christians for Israel Chair in Medical Research and by the doctoral scholarship granted to T.D. by the Ministry of Science and Technology, Israel.

Funders	Funder number
Israel Cancer Research Fund
Ministry of Science and Technology
Israel Science Foundation	749/14
Ministry of science and technology, Israel

Keywords

Theranostics
cancer imaging and therapy
gold nanoparticles
molecular CT imaging
size effect
tumor uptake

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1117/12.2287392

Cite this

Dreifuss, T., Betzer, O., Barnoy, E., Motiei, M., & Popovtzer, R. (2018). The effect of nanoparticle size on theranostic systems: The optimal particle size for imaging is not necessarily optimal for drug delivery. In D. V. Nicolau, A. N. Cartwright, & D. Fixler (Eds.), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV Article 1050613 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10506). SPIE. https://doi.org/10.1117/12.2287392

Dreifuss, Tamar ; Betzer, Oshra ; Barnoy, Eran et al. / The effect of nanoparticle size on theranostic systems : The optimal particle size for imaging is not necessarily optimal for drug delivery. Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV. editor / Dan V. Nicolau ; Alexander N. Cartwright ; Dror Fixler. SPIE, 2018. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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abstract = "Theranostics is an emerging field, defined as combination of therapeutic and diagnostic capabilities in the same material. Nanoparticles are considered as an efficient platform for theranostics, particularly in cancer treatment, as they offer substantial advantages over both common imaging contrast agents and chemotherapeutic drugs. However, the development of theranostic nanoplatforms raises an important question: Is the optimal particle for imaging also optimal for therapy? Are the specific parameters required for maximal drug delivery, similar to those required for imaging applications? Herein, we examined this issue by investigating the effect of nanoparticle size on tumor uptake and imaging. Anti-epidermal growth factor receptor (EGFR)-conjugated gold nanoparticles (GNPs) in different sizes (diameter range: 20-120 nm) were injected to tumor bearing mice and their uptake by tumors was measured, as well as their tumor visualization capabilities as tumor-targeted CT contrast agent. Interestingly, the results showed that different particles led to highest tumor uptake or highest contrast enhancement, meaning that the optimal particle size for drug delivery is not necessarily optimal for tumor imaging. These results have important implications on the design of theranostic nanoplatforms.",

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Dreifuss, T, Betzer, O, Barnoy, E, Motiei, M & Popovtzer, R 2018, The effect of nanoparticle size on theranostic systems: The optimal particle size for imaging is not necessarily optimal for drug delivery. in DV Nicolau, AN Cartwright & D Fixler (eds), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV., 1050613, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10506, SPIE, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV 2018, San Francisco, United States, 30/01/18. https://doi.org/10.1117/12.2287392

The effect of nanoparticle size on theranostic systems: The optimal particle size for imaging is not necessarily optimal for drug delivery. / Dreifuss, Tamar; Betzer, Oshra; Barnoy, Eran et al.
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV. ed. / Dan V. Nicolau; Alexander N. Cartwright; Dror Fixler. SPIE, 2018. 1050613 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10506).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Dreifuss T, Betzer O, Barnoy E, Motiei M, Popovtzer R. The effect of nanoparticle size on theranostic systems: The optimal particle size for imaging is not necessarily optimal for drug delivery. In Nicolau DV, Cartwright AN, Fixler D, editors, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV. SPIE. 2018. 1050613. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2287392

The effect of nanoparticle size on theranostic systems: The optimal particle size for imaging is not necessarily optimal for drug delivery

Abstract

Publication series

Conference

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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