TY - JOUR
T1 - The effect of methylphenidate on social cognition and oxytocin in children with attention deficit hyperactivity disorder
AU - Levi-Shachar, Orit
AU - Gvirts, Hila Z.
AU - Goldwin, Yiftach
AU - Bloch, Yuval
AU - Shamay-Tsoory, Simone
AU - Zagoory-Sharon, Orna
AU - Feldman, Ruth
AU - Maoz, Hagai
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to American College of Neuropsychopharmacology.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - The current study aimed to explore the possible effect of stimulants on oxytocin (OT), a neuropeptide which regulates social behavior, as a mediator of the pro-social effect of methylphenidate (MPH) in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls (HCs). Utilizing a double-blind placebo-controlled design, we compared the performance of 50 children with ADHD and 40 HCs in “theory of mind” (ToM) tasks and examined the effect of a single dose of MPH/placebo on ToM and salivary OT levels in children with ADHD at baseline and following an interpersonal interaction. Children with ADHD displayed significantly poorer ToM performance; however, following MPH administration, their performance normalized and differences between children with ADHD and HC were no longer found. Salivary OT levels at baseline did not differ between children with ADHD and HCs. However, after a parent–child interaction, OT levels were significantly higher in the HC group compared to children with ADHD. Administration of MPH attenuated this difference such that after parent–child interaction differences in OT levels between children with ADHD and HC were no longer found. In the ADHD group, OT levels decreased from administration of placebo to the parent–child interaction. However, the administration of MPH to children with ADHD was associated with an increase in OT levels after the parent–child interaction. We conclude that OT might play a role as a mediator of social deficits in children with ADHD and that the reactivity of the OT system to social interaction in children with ADHD might be impaired. Stimulants may improve ToM and social functions in children with ADHD via its impact on the OT system. PRS: OT and Social Cognition in Children with ADHD: Impact of MPH.
AB - The current study aimed to explore the possible effect of stimulants on oxytocin (OT), a neuropeptide which regulates social behavior, as a mediator of the pro-social effect of methylphenidate (MPH) in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls (HCs). Utilizing a double-blind placebo-controlled design, we compared the performance of 50 children with ADHD and 40 HCs in “theory of mind” (ToM) tasks and examined the effect of a single dose of MPH/placebo on ToM and salivary OT levels in children with ADHD at baseline and following an interpersonal interaction. Children with ADHD displayed significantly poorer ToM performance; however, following MPH administration, their performance normalized and differences between children with ADHD and HC were no longer found. Salivary OT levels at baseline did not differ between children with ADHD and HCs. However, after a parent–child interaction, OT levels were significantly higher in the HC group compared to children with ADHD. Administration of MPH attenuated this difference such that after parent–child interaction differences in OT levels between children with ADHD and HC were no longer found. In the ADHD group, OT levels decreased from administration of placebo to the parent–child interaction. However, the administration of MPH to children with ADHD was associated with an increase in OT levels after the parent–child interaction. We conclude that OT might play a role as a mediator of social deficits in children with ADHD and that the reactivity of the OT system to social interaction in children with ADHD might be impaired. Stimulants may improve ToM and social functions in children with ADHD via its impact on the OT system. PRS: OT and Social Cognition in Children with ADHD: Impact of MPH.
UR - http://www.scopus.com/inward/record.url?scp=85076329160&partnerID=8YFLogxK
U2 - 10.1038/s41386-019-0522-5
DO - 10.1038/s41386-019-0522-5
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C2 - 31514201
AN - SCOPUS:85076329160
SN - 0893-133X
VL - 45
SP - 367
EP - 373
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 2
ER -