The effect of ethanol on metabolic, hemodynamic and electrical responses to cortical spreading depression

Judith Sonn, Avraham Mayevsky

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Alcohol induces a decrease in cerebral blood flow (CBF) and metabolic rate, mitochondrial damage and other impairments in brain function and structure. Cortical spreading depression (CSD) is a phenomenon causing changes in ion homeostasis and raises energy demand, mitochondrial activity and CBF. It is of great interest to study the effect of ethanol on brain response under a challenge of increasing oxygen demand by inducing CSD. A special multisite assembly (MSA) was constructed to evaluate metabolic (mitochondrial NADH), hemodynamic (reflectance) and electrical (DC potential) activities from four parasagittally adjacently arranged areas of the cerebral cortex, continuously and simultaneously in vivo. Three CSD cycles were initiated every 30 min before and after ethanol or saline infusion over 4.5 h. During CSD amplitude changes of reflectance, NADH and DC potential as well as propagation rates and wave frequency were calculated. After ethanol infusion CSD showed a decrease in the negative shift of the DC potential, and alterations in the biphasic responses in reflectance, which may indicate alteration in blood volume: unclear responses in the initial vasoconstriction phase and a significant increase in the subsequent vasodilatation phase. The reduction in the amplitude of the NADH oxidation cycle may depict a decrease in energy production, which could also be indicated by a decline in wave frequency (prolonging the recovery phase of the CSD). The decrease in propagation rate indicates a decline in tissue excitability and in the CSD initiation mechanism induced by ethanol treatment.

Original languageEnglish
Pages (from-to)174-186
Number of pages13
JournalBrain Research
Volume908
Issue number2
DOIs
StatePublished - 27 Jul 2001

Bibliographical note

Funding Information:
This work was supported by the Health Sciences Research Center and the University Research Committee, Bar-Ilan University, Ramat Gan, Israel. We would like to thank Rachel Drummer-Levy for her help in the statistical analysis.

Funding

This work was supported by the Health Sciences Research Center and the University Research Committee, Bar-Ilan University, Ramat Gan, Israel. We would like to thank Rachel Drummer-Levy for her help in the statistical analysis.

FundersFunder number
Health Sciences Research Center
University Research Committee, Bar-Ilan University

    Keywords

    • Cortical spreading depression
    • DC potential
    • Mitochondrial NADH

    Fingerprint

    Dive into the research topics of 'The effect of ethanol on metabolic, hemodynamic and electrical responses to cortical spreading depression'. Together they form a unique fingerprint.

    Cite this