The effect of ELOVL6 fatty acid elongase inhibition on the expression of genes associated with the metastasis of breast cancer

G. S. Zakharova; A. A. Poloznikov; L. A. Astakhova; M. P. Raigorodskaya; Z. B. Khesina; K. A. Fomicheva; A. K. Buryak; B. Ya Alekseev

doi:10.1007/s11172-018-2374-2

The effect of ELOVL6 fatty acid elongase inhibition on the expression of genes associated with the metastasis of breast cancer

G. S. Zakharova, A. A. Poloznikov, L. A. Astakhova, M. P. Raigorodskaya, Z. B. Khesina, K. A. Fomicheva, A. K. Buryak, B. Ya Alekseev

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The paper addresses the effect of a new fatty acid elongase 6 (ELOVL6) inhibitor on the migration of breast cancer cells (estrogen receptor positive MCF7 cells and estrogen receptor negative MDA-MB-231 cells) and expression of genes associated with the epithelial-mesenchymal transition, the first stage of tumor metastasis. It was shown that inhibition of the synthesis of C18 fatty acids does not change the migration activity or expression of transcription factors regulating the epithelial-mesenchymal transition. At the same time, the inhibition of ELOVL6 resulted in overexpression of genes associated with breast cancer development and metastasis in vivo (EGFR, CASP4 and VEGFA).

Original language	English
Pages (from-to)	2307-2315
Number of pages	9
Journal	Russian Chemical Bulletin
Volume	67
Issue number	12
DOIs	https://doi.org/10.1007/s11172-018-2374-2
State	Published - 1 Dec 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Funding

This work was financially supported by the Ministry of Education and Science of the Russian Federation (Federal Target Program "Research and Development in the Priority Areas of the Science and Engineering Sector of Russia for the 2014—2020 years"; UIPNI RFMEFI61316X0058).

Funders	Funder number
UIPNI	RFMEFI61316X0058
Ministry of Education and Science of the Russian Federation

Keywords

ELOVL6
EMT
MCF7
MDA-MB-231
breast cancer
epithelial-mesenchymal transition
inhibitor
metastasis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11172-018-2374-2

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title = "The effect of ELOVL6 fatty acid elongase inhibition on the expression of genes associated with the metastasis of breast cancer",

abstract = "The paper addresses the effect of a new fatty acid elongase 6 (ELOVL6) inhibitor on the migration of breast cancer cells (estrogen receptor positive MCF7 cells and estrogen receptor negative MDA-MB-231 cells) and expression of genes associated with the epithelial-mesenchymal transition, the first stage of tumor metastasis. It was shown that inhibition of the synthesis of C18 fatty acids does not change the migration activity or expression of transcription factors regulating the epithelial-mesenchymal transition. At the same time, the inhibition of ELOVL6 resulted in overexpression of genes associated with breast cancer development and metastasis in vivo (EGFR, CASP4 and VEGFA).",

keywords = "ELOVL6, EMT, MCF7, MDA-MB-231, breast cancer, epithelial-mesenchymal transition, inhibitor, metastasis",

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AU - Zakharova, G. S.

AU - Poloznikov, A. A.

AU - Astakhova, L. A.

AU - Raigorodskaya, M. P.

AU - Khesina, Z. B.

AU - Fomicheva, K. A.

AU - Buryak, A. K.

AU - Alekseev, B. Ya

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AB - The paper addresses the effect of a new fatty acid elongase 6 (ELOVL6) inhibitor on the migration of breast cancer cells (estrogen receptor positive MCF7 cells and estrogen receptor negative MDA-MB-231 cells) and expression of genes associated with the epithelial-mesenchymal transition, the first stage of tumor metastasis. It was shown that inhibition of the synthesis of C18 fatty acids does not change the migration activity or expression of transcription factors regulating the epithelial-mesenchymal transition. At the same time, the inhibition of ELOVL6 resulted in overexpression of genes associated with breast cancer development and metastasis in vivo (EGFR, CASP4 and VEGFA).

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KW - EMT

KW - MCF7

KW - MDA-MB-231

KW - breast cancer

KW - epithelial-mesenchymal transition

KW - inhibitor

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The effect of ELOVL6 fatty acid elongase inhibition on the expression of genes associated with the metastasis of breast cancer

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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