The Effect of Clomiphene Citrate and Tamoxifen on the Cervical Mucus

Ron Tepper, Bruno Lunenfeld, Joseph Shalev, Jardena Ovadia, Josef Blankstein

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The anti‐estrogenic effect of clomiphene citrate (CC) and tamoxifen (TMX) on cervical mucus was evaluated in a prospective crossover study. Ten women underwent randomized alternate cyclical treatment with either 100 mg CC, 40 mg TMX daily, or with placebo. The effect of CC, TMX and placebo on serum estradiol (E2), cervical mucus secretion and on the development of ovarian follicles was evaluated. Compared with placebo, treatment with CC and TMX significantly increased the number of mature ovarian follicles on the day of assumed ovulation (p <0.05), elevated E, secretion (p <0.05) and decreased cervical score (p <0.05). It can be concluded that anti‐estrogenic agents reduced the secretion of cervical mucus. However, in most cases, the excessive E, production due to multiple follicular growth overcomes the anti‐estrogenic effect. 1988 Acta Obstet Gynecol Scand

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalActa Obstetricia et Gynecologica Scandinavica
Issue number4
StatePublished - Jan 1988
Externally publishedYes


  • Cervix mucus
  • anti‐estrogens
  • estradiol


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