The dynamic pathway of nuclear RNA in eukaryotes

Jonathan Sheinberger, Yaron Shav-Tal

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The passage of mRNA molecules from the site of synthesis, through the nucleoplasm and the nuclear pore, en route to the cytoplasm, might appear straightforward. Nonetheless, several decades of detailed examination of this pathway, from high resolution electron microscopy in fixed specimens, through the development of immuno-detection techniques and fluorescence toolkits, to the current era of live-cell imaging, show this to be an eventful journey. In addition to mRNAs, several species of noncoding RNAs travel and function in the nucleus, some being retained within throughout their lifetime. This review will highlight the nucleoplasmic paths taken by mRNAs and noncoding RNAs in eukaryotic cells with special focus on live-cell data and in concurrence with the biophysical nature of the nucleus.

Original languageEnglish
Pages (from-to)195-205
Number of pages11
Issue number3
StatePublished - 2013

Bibliographical note

Funding Information:
Y.S.-T. is supported by the European Research Council (ERC).


  • Inter-chromatin
  • Live-cell imaging
  • Nuceloplasm
  • RNA dynamics
  • mRNA export


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