The cytoskeletal network controls c-Jun translation in a UTR-dependent manner

P. Polak; A. Oren; I. Ben-Dror; D. Steinberg; S. Sapoznik; A. Arditi-Duvdevany; L. Vardimon

doi:10.1038/sj.onc.1209114

The cytoskeletal network controls c-Jun translation in a UTR-dependent manner

P. Polak, A. Oren, I. Ben-Dror, D. Steinberg, S. Sapoznik, A. Arditi-Duvdevany, L. Vardimon

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The cytoskeleton is a dynamic network that undergoes restructuring during various cellular events, influencing cell proliferation, differentiation, and apoptosis. Here, we report that accumulation of c-Jun, a member of the AP1 family of transcription factors that play a key role in normal and aberrant cell growth, dramatically increases upon depolymerization of the cytoskeleton, and that, unexpectedly, this increase is controlled translationally. Depolymerization of the actin or microtubule network induces an increase in c-Jun accumulation with no corresponding increase in c-Jun mRNA or in the half-life of the c-Jun protein, but rather in the translatability of its transcript. This increase is mediated by the untranslated regions (UTRs) of c-Jun mRNA, and is not dependent on activated mitogen-activated protein kinase pathways. This novel mechanism of c-Jun regulation might be relevant to physiological conditions in which c-Jun plays a pivotal role.

Original language	English
Pages (from-to)	665-676
Number of pages	12
Journal	Oncogene
Volume	25
Issue number	5
DOIs	https://doi.org/10.1038/sj.onc.1209114
State	Published - 2 Feb 2006
Externally published	Yes

Bibliographical note

Funding Information:
We thank Drs M Cobb, M Karin, Y Kashman, J Kyriakis, R Prywes, R Seger, and E Shaulian for plasmids and reagents, Dr O Elroy-Stein for helpful suggestions and Dr M Yaniv for critical reading of the manuscript. This research was supported by the Israel Cancer Association and the Israel Science Foundation founded by the Israel Academy of Sciences and Humanities.

Funding

We thank Drs M Cobb, M Karin, Y Kashman, J Kyriakis, R Prywes, R Seger, and E Shaulian for plasmids and reagents, Dr O Elroy-Stein for helpful suggestions and Dr M Yaniv for critical reading of the manuscript. This research was supported by the Israel Cancer Association and the Israel Science Foundation founded by the Israel Academy of Sciences and Humanities.

Funders	Funder number
Israel Academy of Sciences and Humanities
Israel Cancer Association
Israel Science Foundation

Keywords

Cell density
Cytoskeletal network
Translation control
UTRs
c-Jun

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.onc.1209114

Cite this

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The cytoskeletal network controls c-Jun translation in a UTR-dependent manner

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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