The control of blepharospasm by essential fatty acids

David I. Mostofsky, Shlomo Yehuda, Sharon Rabinovitz, Ralph Carasso

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Dopamine depletion induced by administration of Ro4-1284 produces a condition of rapid and repeated eye blinking in rats. This condition mimics the human disorder, blepharospasm, which often accompanies parkinsonism and other dopamine deficiency disorders. When given a 3-week course of a compound (SR-3) developed from a specific ratio of two free polyunsaturated fatty acids - linoleic acid and α-linolenic acid - the eye blinking rate following administration of Ro4-1284 is reduced to saline and no drug control levels. These results suggest a favorable prospect for essential fatty acids in general, and SR-3 in particular, to provide an improved therapeutic option for the clinical management of benign essential blepharospasm. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
Issue number3
StatePublished - 2000


  • Blepharospasm
  • Dopamine deficiency
  • Fatty acids
  • Linoleic acid
  • α-linolenic acid


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