The consequence of natural selection on genetic variation in the mouse

Eli Reuveni, Ewan Birney, Cornelius T. Gross

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Laboratory mouse strains are known to have emerged from recent interbreeding between individuals of Mus musculus isolated populations. As a result of this breeding history, the collection of polymorphisms observed between laboratory mouse strains is likely to harbor the effects of natural selection between reproductively isolated populations. Until now no study has systematically investigated the consequences of this breeding history on gene evolution. Here we have used a novel, unbiased evolutionary approach to predict the founder origin of laboratory mouse strains and to assess the balance between ancient and newly emerged mutations in the founder subspecies. Our results confirm a contribution from at least four distinct subspecies. Additionally, our method allowed us to identify regions of relaxed selective constraint among laboratory mouse strains. This unique structure of variation is likely to have significant consequences on the use of mouse to find genes underlying phenotypic variation.

Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalGenomics
Volume95
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

Bibliographical note

Funding Information:
We thank Nadia Rosenthal for financial support. This work was supported in part by a grant from NARSAD (C.T.G.).

Funding

We thank Nadia Rosenthal for financial support. This work was supported in part by a grant from NARSAD (C.T.G.).

FundersFunder number
Nadia Rosenthal
National Alliance for Research on Schizophrenia and Depression

    Keywords

    • Laboratory mouse strains
    • Mouse evolution
    • Natural selection
    • Phylogenetic reconstruction
    • SNP

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