@article{993c9fa5ad1b42b2b0f96795ae1c90f3,
title = "The conjugates of gold nanorods and chlorin e6 for enhancing the fluorescence detection and photodynamic therapy of cancers",
abstract = "Gold nanorods (AuNRs) were conjugated with chlorin e6 (Ce6), a commonly used photosensitizer, to form AuNRs-Ce6 by electrostatic binding. Due to the strong surface plasmon resonance coupling, the fluorescence of conjugated Ce6 was enhanced 3-fold and the production of singlet oxygen was increased 1.4-fold. AuNRs-Ce6 were taken up by the HeLa and KB cell lines more easily than free Ce6, enhancing the intracellular delivery of Ce6. The increased cellular amount of Ce6 leads to a 3-fold more efficient photodynamic killing of these two cell lines. This demonstrates the potential of this approach to improve photodynamic detection and therapy of cancers.",
author = "Xiao Huang and Tian, {Xue Jiao} and Yang, {Wu Li} and Benjamin Ehrenberg and Chen, {Ji Yao}",
year = "2013",
month = oct,
day = "14",
doi = "10.1039/c3cp44227f",
language = "אנגלית",
volume = "15",
pages = "15727--15733",
journal = "Physical Chemistry Chemical Physics",
issn = "1463-9076",
publisher = "Royal Society of Chemistry",
number = "38",
}
