Abstract
SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD+-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the implication of SIRT6 in the biology of cancer and the relevance to organism homeostasis and lifespan.
| Original language | English |
|---|---|
| Pages (from-to) | 108-118 |
| Number of pages | 11 |
| Journal | Carcinogenesis |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2016 |
Bibliographical note
Publisher Copyright:© The Author 2015. Published by Oxford University Press. All rights reserved.
Funding
This study was supported by the Israel Science Foundation, I-Core Foundation, Israeli Ministry of Health, The National Network of Excellence in Neuroscience-TEVA Ltd. The Israeli Ministry of Health, ESFD, D-Cure and the ERC: European Research Council. This study was supported by the Israel Science Foundation,I-Core Foundation, Israeli Ministry of Health, The National Network of Excellence in Neuroscience-TEVA Ltd. The Israeli Ministry of Health, ESFD, D-Cure and the ERC: European Research Council.
| Funders | Funder number |
|---|---|
| I-Core Foundation | |
| Israel Science Foundation,I-Core Foundation | |
| National Network of Excellence in Neuroscience-TEVA Ltd | |
| National Network of Excellence in Neuroscience-TEVA Ltd | |
| European Commission | |
| Israel Science Foundation | |
| Ministry of Health, State of Israel |
