The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures

Michael S. Kraus; James M. Gold; Deanna M. Barch; Trina M. Walker; Charlotte A. Chun; Robert W. Buchanan; John G. Csernansky; Donald C. Goff; Michael F. Green; L. Fredrik Jarskog; Daniel C. Javitt; David Kimhy; Jeffrey A. Lieberman; Joseph P. McEvoy; Raquelle I. Mesholam-Gately; Larry J. Seidman; M. Patricia Ball; Robert S. Kern; Robert P. McMahon; James Robinson; Stephen R. Marder; Richard S.E. Keefe

doi:10.1016/j.scog.2019.100161

The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures

Michael S. Kraus, James M. Gold, Deanna M. Barch, Trina M. Walker, Charlotte A. Chun, Robert W. Buchanan, John G. Csernansky, Donald C. Goff, Michael F. Green, L. Fredrik Jarskog, Daniel C. Javitt, David Kimhy, Jeffrey A. Lieberman, Joseph P. McEvoy, Raquelle I. Mesholam-Gately, Larry J. Seidman, M. Patricia Ball, Robert S. Kern, Robert P. McMahon, James RobinsonStephen R. Marder, Richard S.E. Keefe

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Abstract

In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.

Original language	English
Article number	100161
Journal	Schizophrenia Research: Cognition
Volume	19
DOIs	https://doi.org/10.1016/j.scog.2019.100161
State	Published - Mar 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019

Funding

This study was funded by National Institute of Mental Health Contract HHSN278200441003C to the University of California, Los Angeles (SRM, Principal Investigator). Double-blind medications were provided by Merck and Company.

Funders	Funder number
Merck and Company
National Institute of Mental Health	HHSN278200441003C

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.scog.2019.100161

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Kraus, M. S., Gold, J. M., Barch, D. M., Walker, T. M., Chun, C. A., Buchanan, R. W., Csernansky, J. G., Goff, D. C., Green, M. F., Jarskog, L. F., Javitt, D. C., Kimhy, D., Lieberman, J. A., McEvoy, J. P., Mesholam-Gately, R. I., Seidman, L. J., Ball, M. P., Kern, R. S., McMahon, R. P., ... Keefe, R. S. E. (2020). The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures. Schizophrenia Research: Cognition, 19, Article 100161. https://doi.org/10.1016/j.scog.2019.100161

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abstract = "In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.",

author = "Kraus, {Michael S.} and Gold, {James M.} and Barch, {Deanna M.} and Walker, {Trina M.} and Chun, {Charlotte A.} and Buchanan, {Robert W.} and Csernansky, {John G.} and Goff, {Donald C.} and Green, {Michael F.} and Jarskog, {L. Fredrik} and Javitt, {Daniel C.} and David Kimhy and Lieberman, {Jeffrey A.} and McEvoy, {Joseph P.} and Mesholam-Gately, {Raquelle I.} and Seidman, {Larry J.} and Ball, {M. Patricia} and Kern, {Robert S.} and McMahon, {Robert P.} and James Robinson and Marder, {Stephen R.} and Keefe, {Richard S.E.}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2020",

month = mar,

doi = "10.1016/j.scog.2019.100161",

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Kraus, MS, Gold, JM, Barch, DM, Walker, TM, Chun, CA, Buchanan, RW, Csernansky, JG, Goff, DC, Green, MF, Jarskog, LF, Javitt, DC, Kimhy, D, Lieberman, JA, McEvoy, JP, Mesholam-Gately, RI, Seidman, LJ, Ball, MP, Kern, RS, McMahon, RP, Robinson, J, Marder, SR & Keefe, RSE 2020, 'The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures', Schizophrenia Research: Cognition, vol. 19, 100161. https://doi.org/10.1016/j.scog.2019.100161

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T1 - The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial

T2 - Psychometric properties and correlations with standard measures

AU - Kraus, Michael S.

AU - Gold, James M.

AU - Barch, Deanna M.

AU - Walker, Trina M.

AU - Chun, Charlotte A.

AU - Buchanan, Robert W.

AU - Csernansky, John G.

AU - Goff, Donald C.

AU - Green, Michael F.

AU - Jarskog, L. Fredrik

AU - Javitt, Daniel C.

AU - Kimhy, David

AU - Lieberman, Jeffrey A.

AU - McEvoy, Joseph P.

AU - Mesholam-Gately, Raquelle I.

AU - Seidman, Larry J.

AU - Ball, M. Patricia

AU - Kern, Robert S.

AU - McMahon, Robert P.

AU - Robinson, James

AU - Marder, Stephen R.

AU - Keefe, Richard S.E.

PY - 2020/3

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AB - In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.

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The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures

Abstract

Bibliographical note

Funding

UN SDGs

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