The cardiac methylome: A hidden layer of RNA modifications to regulate gene expression

K. Shanmugha Rajan, Subbiah Ramasamy, Venkata Naga Srikanth Garikipati, Vemparthan Suvekbala

Research output: Contribution to journalReview articlepeer-review


Post-transcriptional RNA modification has been observed in all kingdoms of life and more than a hundred different types of RNA modifications decorate the chemical and topological properties of these ribose nucleotides. These RNA modifications can potentially alter the RNA structure and also affect the binding affinity of proteins, thus regulating the mRNA stability as well as translation. Emerging evidence suggest that these modifications are not static, but are dynamic; vary upon different cues and are cell-type or tissue-specific. The cardiac transcriptome is not exceptional to such RNA modifications and is enriched with the abundant base methylation such as N6-methyladenosine (m6A) and also 2’-O-Methylation (Nm). In this review we will focus on the technologies available to map these modifications and as well as the contribution of these post-transcriptional modifications during various pathological conditions of the heart.

Original languageEnglish
Pages (from-to)40-51
Number of pages12
JournalJournal of Molecular and Cellular Cardiology
StatePublished - Mar 2021

Bibliographical note

Funding Information:
K.S.R is supported by the President's doctoral scholarship, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University , Israel. V.N.S.G. is supported by American Heart Association Career Development Award 18CDA34110277 and start-up funds, Ohio state university . The authors acknowledge Dr. Sarin Palakkal for assistance with the chemical structures in Fig. 1 .

Publisher Copyright:
© 2020 Elsevier Ltd


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