Abstract
Post-transcriptional RNA modification has been observed in all kingdoms of life and more than a hundred different types of RNA modifications decorate the chemical and topological properties of these ribose nucleotides. These RNA modifications can potentially alter the RNA structure and also affect the binding affinity of proteins, thus regulating the mRNA stability as well as translation. Emerging evidence suggest that these modifications are not static, but are dynamic; vary upon different cues and are cell-type or tissue-specific. The cardiac transcriptome is not exceptional to such RNA modifications and is enriched with the abundant base methylation such as N6-methyladenosine (m6A) and also 2’-O-Methylation (Nm). In this review we will focus on the technologies available to map these modifications and as well as the contribution of these post-transcriptional modifications during various pathological conditions of the heart.
| Original language | English |
|---|---|
| Pages (from-to) | 40-51 |
| Number of pages | 12 |
| Journal | Journal of Molecular and Cellular Cardiology |
| Volume | 152 |
| DOIs | |
| State | Published - Mar 2021 |
Bibliographical note
Publisher Copyright:© 2020 Elsevier Ltd
Funding
K.S.R is supported by the President's doctoral scholarship, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University , Israel. V.N.S.G. is supported by American Heart Association Career Development Award 18CDA34110277 and start-up funds, Ohio state university . The authors acknowledge Dr. Sarin Palakkal for assistance with the chemical structures in Fig. 1 .
| Funders | Funder number |
|---|---|
| Mina and Everard Goodman Faculty of Life Sciences | |
| American Heart Association | 18CDA34110277 |
| Ohio State University | |
| Bar-Ilan University |