The blood brain barrier and neuropsychiatric lupus: new perspectives in light of advances in understanding the neuroimmune interface

Ariel D. Stock; Sivan Gelb; Ofer Pasternak; Ayal Ben-Zvi; Chaim Putterman

doi:10.1016/j.autrev.2017.04.008

The blood brain barrier and neuropsychiatric lupus: new perspectives in light of advances in understanding the neuroimmune interface

Ariel D. Stock
, Sivan Gelb
, Ofer Pasternak
, Ayal Ben-Zvi
, Chaim Putterman

Research output: Contribution to journal › Review article › peer-review

72 Scopus citations

Abstract

Experts have previously postulated a linkage between lupus associated vascular pathology and abnormal brain barriers in the immunopathogenesis of neuropsychiatric lupus. Nevertheless, there are some discrepancies between the experimental evidence, or its interpretation, and the working hypotheses prevalent in this field; specifically, that a primary contributor to neuropsychiatric disease in lupus is permeabilization of the blood brain barrier. In this commonly held view, any contribution of the other known brain barriers, including the blood-cerebrospinal fluid and meningeal barriers, is mostly excluded from the discussion. In this review we will shed light on some of the blood brain barrier hypotheses and try to trace their roots. In addition, we will suggest new research directions to allow for confirmation of alternative interpretations of the experimental evidence linking the pathology of intra-cerebral vasculature to the pathogenesis of neuropsychiatric lupus.

Original language	English
Pages (from-to)	612-619
Number of pages	8
Journal	Autoimmunity Reviews
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.autrev.2017.04.008
State	Published - Jun 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

Funding

These studies were supported by training grant T32-GM007288 to A. Stock from the NIH; research grants from the National Institute of Mental Health (MH108574) and the National Institute of Biomedical Imaging and Bioengineering (EB015902) to O. Pasternak; research grants from the Abisch-Frenkel Foundation (15/H1) and The Leona M. and Harry B. Helmsley Charitable Trust (2015PG-ISL007) to A. Ben-Zvi; and a research grant from the National Institute of Arthritis and Musculoskeletal Diseases (AR065594) to C. Putterman. We wish to thank Mr. Yitchak Yadegari for help with graphical illustrations.

Funders	Funder number
National Institutes of Health
National Institute of Mental Health	MH108574
National Institute of General Medical Sciences	T32GM007288
National Institute of Arthritis and Musculoskeletal and Skin Diseases	AR065594
National Institute of Biomedical Imaging and Bioengineering	EB015902
Leona M. and Harry B. Helmsley Charitable Trust
Abisch-Frenkel-Stiftung	15/H1

Keywords

Blood-CSF barrier
Blood-brain-barrier
Choroid plexus
Glymphatics
Neuropsychiatric lupus
SLE

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10.1016/j.autrev.2017.04.008

Cite this

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abstract = "Experts have previously postulated a linkage between lupus associated vascular pathology and abnormal brain barriers in the immunopathogenesis of neuropsychiatric lupus. Nevertheless, there are some discrepancies between the experimental evidence, or its interpretation, and the working hypotheses prevalent in this field; specifically, that a primary contributor to neuropsychiatric disease in lupus is permeabilization of the blood brain barrier. In this commonly held view, any contribution of the other known brain barriers, including the blood-cerebrospinal fluid and meningeal barriers, is mostly excluded from the discussion. In this review we will shed light on some of the blood brain barrier hypotheses and try to trace their roots. In addition, we will suggest new research directions to allow for confirmation of alternative interpretations of the experimental evidence linking the pathology of intra-cerebral vasculature to the pathogenesis of neuropsychiatric lupus.",

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The blood brain barrier and neuropsychiatric lupus: new perspectives in light of advances in understanding the neuroimmune interface

Abstract

Bibliographical note

Funding

Keywords

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