The bioconversion of 17α-ethynyl steroids with 11α-hydroxylase ofRhizopus nigricans

Marija Z ̌akelj-Mavric ̌; Igor Belic ̌; Hugo E. Gottlieb

doi:10.1016/0378-1097(86)90197-7

The bioconversion of 17α-ethynyl steroids with 11α-hydroxylase ofRhizopus nigricans

Marija Z ̌akelj-Mavric ̌
, Igor Belic ̌
, Hugo E. Gottlieb

Department of Chemistry

Edvard Kardelj University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The bioconversion of 17α-ethynyl steroids was effected with 11α-hydroxylase ofRhizopus nigricans. 7β-Hydroxyethisterone was found after the bioconversion of ethisterone, and 10β- and 6β-hydroxy derivatives after the bioconversion of norethisterone. It seems that the ethynyl group prevents steroid-enzyme binding in the normal mode and thus inhibits the formation of an 11α-hydroxylated product.

Original language	English
Pages (from-to)	117-120
Number of pages	4
Journal	FEMS Microbiology Letters
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/0378-1097(86)90197-7
State	Published - Jan 1986

Bibliographical note

Funding Information:
This work was supportedb y the ResearchC om-munityo f Slovenia.W e would like to thank Dr. B.

Funding

This work was supportedb y the ResearchC om-munityo f Slovenia.W e would like to thank Dr. B.

Funders
ResearchC om-munityo f Slovenia.W

Keywords

Induced 11α-hydroxylase
ethisterone
norethisterone

Access to Document

10.1016/0378-1097(86)90197-7

Cite this

@article{03ad0ceb70964aa9b943397f048d68f8,

title = "The bioconversion of 17α-ethynyl steroids with 11α-hydroxylase ofRhizopus nigricans",

abstract = "The bioconversion of 17α-ethynyl steroids was effected with 11α-hydroxylase ofRhizopus nigricans. 7β-Hydroxyethisterone was found after the bioconversion of ethisterone, and 10β- and 6β-hydroxy derivatives after the bioconversion of norethisterone. It seems that the ethynyl group prevents steroid-enzyme binding in the normal mode and thus inhibits the formation of an 11α-hydroxylated product.",

keywords = "Induced 11α-hydroxylase, ethisterone, norethisterone",

author = "\{Z{\v }akelj-Mavric{\v }\}, Marija and \{Belic{\v }\}, Igor and Gottlieb, \{Hugo E.\}",

note = "Funding Information: This work was supportedb y the ResearchC om-munityo f Slovenia.W e would like to thank Dr. B.",

year = "1986",

month = jan,

doi = "10.1016/0378-1097(86)90197-7",

language = "אנגלית",

volume = "33",

pages = "117--120",

journal = "FEMS Microbiology Letters",

issn = "0378-1097",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - The bioconversion of 17α-ethynyl steroids with 11α-hydroxylase ofRhizopus nigricans

AU - Z ̌akelj-Mavric ̌, Marija

AU - Belic ̌, Igor

AU - Gottlieb, Hugo E.

N1 - Funding Information: This work was supportedb y the ResearchC om-munityo f Slovenia.W e would like to thank Dr. B.

PY - 1986/1

Y1 - 1986/1

N2 - The bioconversion of 17α-ethynyl steroids was effected with 11α-hydroxylase ofRhizopus nigricans. 7β-Hydroxyethisterone was found after the bioconversion of ethisterone, and 10β- and 6β-hydroxy derivatives after the bioconversion of norethisterone. It seems that the ethynyl group prevents steroid-enzyme binding in the normal mode and thus inhibits the formation of an 11α-hydroxylated product.

AB - The bioconversion of 17α-ethynyl steroids was effected with 11α-hydroxylase ofRhizopus nigricans. 7β-Hydroxyethisterone was found after the bioconversion of ethisterone, and 10β- and 6β-hydroxy derivatives after the bioconversion of norethisterone. It seems that the ethynyl group prevents steroid-enzyme binding in the normal mode and thus inhibits the formation of an 11α-hydroxylated product.

KW - Induced 11α-hydroxylase

KW - ethisterone

KW - norethisterone

UR - https://www.scopus.com/pages/publications/0022630653

U2 - 10.1016/0378-1097(86)90197-7

DO - 10.1016/0378-1097(86)90197-7

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0022630653

SN - 0378-1097

VL - 33

SP - 117

EP - 120

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 1

ER -

The bioconversion of 17α-ethynyl steroids with 11α-hydroxylase ofRhizopus nigricans

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this