The bioconversion of 17α-ethynyl steroids with 11α-hydroxylase ofRhizopus nigricans

Marija Z ̌akelj-Mavric ̌; Igor Belic ̌; Hugo E. Gottlieb

doi:10.1016/0378-1097(86)90197-7

The bioconversion of 17α-ethynyl steroids with 11α-hydroxylase ofRhizopus nigricans

Marija Z ̌akelj-Mavric ̌, Igor Belic ̌, Hugo E. Gottlieb

Department of Chemistry

Edvard Kardelj University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The bioconversion of 17α-ethynyl steroids was effected with 11α-hydroxylase ofRhizopus nigricans. 7β-Hydroxyethisterone was found after the bioconversion of ethisterone, and 10β- and 6β-hydroxy derivatives after the bioconversion of norethisterone. It seems that the ethynyl group prevents steroid-enzyme binding in the normal mode and thus inhibits the formation of an 11α-hydroxylated product.

Original language	English
Pages (from-to)	117-120
Number of pages	4
Journal	FEMS Microbiology Letters
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/0378-1097(86)90197-7
State	Published - Jan 1986

Bibliographical note

Funding Information:
This work was supportedb y the ResearchC om-munityo f Slovenia.W e would like to thank Dr. B.

Funding

This work was supportedb y the ResearchC om-munityo f Slovenia.W e would like to thank Dr. B.

Funders	Funder number
ResearchC om-munityo f Slovenia.W

Keywords

Induced 11α-hydroxylase
ethisterone
norethisterone

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10.1016/0378-1097(86)90197-7

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title = "The bioconversion of 17α-ethynyl steroids with 11α-hydroxylase ofRhizopus nigricans",

abstract = "The bioconversion of 17α-ethynyl steroids was effected with 11α-hydroxylase ofRhizopus nigricans. 7β-Hydroxyethisterone was found after the bioconversion of ethisterone, and 10β- and 6β-hydroxy derivatives after the bioconversion of norethisterone. It seems that the ethynyl group prevents steroid-enzyme binding in the normal mode and thus inhibits the formation of an 11α-hydroxylated product.",

keywords = "Induced 11α-hydroxylase, ethisterone, norethisterone",

author = "{Z{\v }akelj-Mavric{\v }}, Marija and {Belic{\v }}, Igor and Gottlieb, {Hugo E.}",

note = "Funding Information: This work was supportedb y the ResearchC om-munityo f Slovenia.W e would like to thank Dr. B.",

year = "1986",

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doi = "10.1016/0378-1097(86)90197-7",

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AU - Belic ̌, Igor

AU - Gottlieb, Hugo E.

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AB - The bioconversion of 17α-ethynyl steroids was effected with 11α-hydroxylase ofRhizopus nigricans. 7β-Hydroxyethisterone was found after the bioconversion of ethisterone, and 10β- and 6β-hydroxy derivatives after the bioconversion of norethisterone. It seems that the ethynyl group prevents steroid-enzyme binding in the normal mode and thus inhibits the formation of an 11α-hydroxylated product.

KW - Induced 11α-hydroxylase

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KW - norethisterone

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The bioconversion of 17α-ethynyl steroids with 11α-hydroxylase ofRhizopus nigricans

Abstract

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