The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis

Nimer Assy, Osamah Hussein, Abdallah Khalil, Anthony Luder, Sergio Szvalb, Melia Paizi, Gadi Spira

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

The aim of this study was to examine the effect of the antithrombotic drugs aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of liver cirrhosis and to determine if these two drugs are beneficial in animals with advanced fibrosis or with established cirrhosis undergoing partial hepatectomy. Thioacetamide-induced cirrhotic rats received saline (N=10), aspirin (N=7), or enoxaparin (N=11) for a 5-week treatment period. Hepatic fibrosis was assessed according to METAVIR score. Liver regeneration was monitored using PCNA immunostaining. Compared to untreated cirrhotic controls, a significant improvement in fibrosis grade was observed in the aspirin (43%; χ2=54, P < 0.001) and enoxaparin (36%; χ2=43, P < 0.001) treated groups. Postoperatively, total serum bilirubin levels were lower in the aspirin (1.4±0.18 mg/dl; P < 0.01) and enoxaparin (1.8±0.35 mg/dl; P < 0.05)-treated groups compared to untreated cirrhotic controls (3.2±0.6 mg/dl). Hepatic regenerative activity was significantly improved in the aspirin group (57.3%±6.8%, versus 34.2%±7.2% in untreated cirrhotic controls; P < 0.01) but unchanged in the enoxaparin group. We conclude that aspirin and enoxaparin hold promise as a useful therapy for patients with extensive fibrosis.

Original languageEnglish
Pages (from-to)1187-1193
Number of pages7
JournalDigestive Diseases and Sciences
Volume52
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

Keywords

  • Aspirin
  • Cirrhosis
  • Enoxaparin
  • Fibrosis
  • Liver regeneration
  • Thrombosis

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