Abstract
Background: As the global population ages, there has been a growing incidence of neurodegenerative diseases such as Alzheimer's. More recently, studies exploring the relationship between dietary patterns and neuroimaging outcomes have received particular attention. This systematic literature review provides a structured overview of the association between dietary and nutrient patterns on neuroimaging outcomes and cognitive markers in middle-aged to older adults. A comprehensive literature search was conducted to find relevant articles published from 1999 to date using the following databases Ovid MEDLINE, Embase, PubMed, Scopus and Web of Science. The inclusion criteria for the articles comprised studies reporting on the association between dietary patterns and neuroimaging outcomes, which includes both specific pathological hallmarks of neurodegenerative diseases such as Aβ and tau and nonspecific markers such as structural MRI and glucose metabolism. The risk of bias was evaluated using the Quality Assessment tool from the National Heart, Lung, and Blood Institute of the National Institutes of Health. The results were then organized into a summary of results table, collated based on synthesis without meta-analysis. After conducting the search, 6050 records were extracted and screened for eligibility, with 107 eligible for full-text screening and 42 articles ultimately being included in this review. The results of the systematic review indicate that there is some evidence suggesting that healthy dietary and nutrient patterns were associated with neuroimaging measures, indicative of a protective influence on neurodegeneration and brain ageing. Conversely, unhealthy dietary and nutrient patterns showed evidence pointing to decreased brain volumes, poorer cognition and increased Aβ deposition. Future research should focus on sensitive neuroimaging acquisition and analysis methods, to study early neurodegenerative changes and identify critical periods for interventions and prevention. Systematic Review Registration: PROSPERO registration no, CRD42020194444).
| Original language | English |
|---|---|
| Article number | 101892 |
| Journal | Ageing Research Reviews |
| Volume | 87 |
| DOIs | |
| State | Published - Jun 2023 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2023 Elsevier B.V.
Funding
L.A is funded by Swinburne University Postgraduate Research Award (SUPRA). S.G. is funded by Australian Research Training Program Stipends . W.M. is currently funded by an Alfred Deakin Postdoctoral Research Fellowship and a Multiple Sclerosis Research Australia early-career fellowship. Wolfgang has previously received funding from the NHMRC , Clifford Craig Foundation, Cancer Council Queensland and university grants/fellowships from La Trobe University, Deakin University, University of Queensland, and Bond University, received industry funding and has attended events funded by Cobram Estate Pty. Ltd , received travel funding from Nutrition Society of Australia , received consultancy funding from Nutrition Research Australia, and has received speakers honoraria from The Cancer Council Queensland and the Princess Alexandra Research Foundation . D.J.W., A.P. have received research funding honoraria, and conference support and consultancy from the nutrition industry. The authors acknowledge the facilities and scientific and technical assistance of the National Imaging Facility, a National Collaborative Research Infrastructure Strategy (NCRIS) capability, Swinburne Neuroimaging Facility, Swinburne University, Melbourne Australia. In addition, we wish to recognize the support of Swinburne University of Technology, Australia, through the Swinburne University Postgraduate Research Award (SUPRA). L.A is funded by Swinburne University Postgraduate Research Award (SUPRA). S.G. is funded by Australian Research Training Program Stipends. W.M. is currently funded by an Alfred Deakin Postdoctoral Research Fellowship and a Multiple Sclerosis Research Australia early-career fellowship. Wolfgang has previously received funding from the NHMRC, Clifford Craig Foundation, Cancer Council Queensland and university grants/fellowships from La Trobe University, Deakin University, University of Queensland, and Bond University, received industry funding and has attended events funded by Cobram Estate Pty. Ltd, received travel funding from Nutrition Society of Australia, received consultancy funding from Nutrition Research Australia, and has received speakers honoraria from The Cancer Council Queensland and the Princess Alexandra Research Foundation. D.J.W. A.P. have received research funding honoraria, and conference support and consultancy from the nutrition industry.
| Funders | Funder number |
|---|---|
| Australian Research Training Program Stipends | |
| Cobram Estate Pty. Ltd | |
| Melbourne Australia | |
| Nutrition Research Australia | |
| Swinburne Neuroimaging Facility | |
| Swinburne University | |
| PA Research Foundation | |
| Clifford Craig Foundation | |
| Multiple Sclerosis Australia | |
| National Health and Medical Research Council | |
| Cancer Council Queensland | |
| La Trobe University | |
| Deakin University | |
| Swinburne University of Technology | |
| Bond University | |
| University of Queensland | |
| Nutrition Society of Australia |
Keywords
- Alzheimer's disease
- Brain volume
- Cognition
- Hippocampus
- Neuroimaging
- Nutrition