The association between serum magnesium levels and community-acquired pneumonia 30-day mortality

Roni Nasser, Mohammad E. Naffaa, Tanya Mashiach, Zaher S. Azzam, Eyal Braun

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Background: Community acquired pneumonia (CAP) is a common illness affecting hundreds of millions worldwide. Few studies have investigated the relationship between serum magnesium levels and outcomes of these patients. We aimed to study the association between serum magnesium levels and 30-day mortality among patients with CAP. Methods: Retrospective overview of patients hospitalized with CAP between January 1, 2010 and December 31, 2016. Participants were analyzed retrospectively in order to identify the risk factors for a primary endpoint of 30-day mortality. Normal levels of magnesium levels in our laboratory varies between 1.35 and 2.4 mg/dl. Results: 3851 patients were included in our cohort. Age > 75 years, blood urea nitrogen (BUN) > 20 mg/dl, hypoalbuminemia, and abnormal levels of magnesium were all associated with increased risk of 30-day mortality. Normal magnesium levels were associated with the lowest mortality rate (14.7%). Notably, within the normal levels, high normal magnesium levels (2-2.4 mg/dl) were correlated with higher mortality rates (30.3%) as compared to levels that ranged between 1.35-2 mg/dl (12.9%). Hypomagnesemia and hypermagnesemia were both associated with excess of 30-day mortality, 18.4 and 50%, respectively. Conclusion: Hypomagnesemia and hypermagnesemia on admission were associated with an increased rate of 30-day mortality among adult patients hospitalized with CAP. Interestingly, magnesium levels within the upper normal limits were associated with higher mortality.

Original languageEnglish
Article number698
JournalBMC Infectious Diseases
Volume18
Issue number1
DOIs
StatePublished - 27 Dec 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 The Author(s).

Keywords

  • Hypermagnesemia
  • Hypomagnesemia
  • Mortality
  • Pneumonia

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