The anti-proliferative effect of lithium chloride on melanoma cells and its reversion by myo-inositol

J. Nordenberg; C. Panet; L. Wasserman; Z. Malik; A. Fuchs; K. H. Stenzel; A. Novogrodsky

doi:10.1038/bjc.1987.9

The anti-proliferative effect of lithium chloride on melanoma cells and its reversion by myo-inositol

J. Nordenberg, C. Panet, L. Wasserman, Z. Malik, A. Fuchs, K. H. Stenzel, A. Novogrodsky

The Mina and Everard Goodman Faculty of Life Sciences

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Abstract

The effect of LiCI on melanoma cell growth and differentiationl was studied in mouse and human melanoma cell lines. LiCI markedly inhibited B16 and HT-144 melanoma cell growth in iitro. Clonogenicity in soft agar of the melanoma cells was also markedly inhibited by LiCl. Pretreatmelnt of B16 mouse melanoma cells with LiCl delayed the appearance of melanoma tumours in syngeneic mice. Growth inhibition of cells was accompanied by morphological and biochemical alterations. LiCl induced cell enlargement and formation of dendrite-like structures. The activity of NADPH cytochrome c reductase, an enzymatic marker of endoplasmic reticulum was significantly (2–3 fold) increased. Addition of myo-inositol to cell cultures partially reversed the anti-proliferative and morphological effects of LiCl on melanoma cells. This finding may suggest that the anti-proliferative effect of LiCl is related to its effect on phosphatidylinositol metabolism.

Original language	English
Pages (from-to)	41-46
Number of pages	6
Journal	British Journal of Cancer
Volume	55
Issue number	1
DOIs	https://doi.org/10.1038/bjc.1987.9
State	Published - Jan 1987

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title = "The anti-proliferative effect of lithium chloride on melanoma cells and its reversion by myo-inositol",

abstract = "The effect of LiCI on melanoma cell growth and differentiationl was studied in mouse and human melanoma cell lines. LiCI markedly inhibited B16 and HT-144 melanoma cell growth in iitro. Clonogenicity in soft agar of the melanoma cells was also markedly inhibited by LiCl. Pretreatmelnt of B16 mouse melanoma cells with LiCl delayed the appearance of melanoma tumours in syngeneic mice. Growth inhibition of cells was accompanied by morphological and biochemical alterations. LiCl induced cell enlargement and formation of dendrite-like structures. The activity of NADPH cytochrome c reductase, an enzymatic marker of endoplasmic reticulum was significantly (2–3 fold) increased. Addition of myo-inositol to cell cultures partially reversed the anti-proliferative and morphological effects of LiCl on melanoma cells. This finding may suggest that the anti-proliferative effect of LiCl is related to its effect on phosphatidylinositol metabolism.",

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AU - Panet, C.

AU - Wasserman, L.

AU - Malik, Z.

AU - Fuchs, A.

AU - Stenzel, K. H.

AU - Novogrodsky, A.

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AB - The effect of LiCI on melanoma cell growth and differentiationl was studied in mouse and human melanoma cell lines. LiCI markedly inhibited B16 and HT-144 melanoma cell growth in iitro. Clonogenicity in soft agar of the melanoma cells was also markedly inhibited by LiCl. Pretreatmelnt of B16 mouse melanoma cells with LiCl delayed the appearance of melanoma tumours in syngeneic mice. Growth inhibition of cells was accompanied by morphological and biochemical alterations. LiCl induced cell enlargement and formation of dendrite-like structures. The activity of NADPH cytochrome c reductase, an enzymatic marker of endoplasmic reticulum was significantly (2–3 fold) increased. Addition of myo-inositol to cell cultures partially reversed the anti-proliferative and morphological effects of LiCl on melanoma cells. This finding may suggest that the anti-proliferative effect of LiCl is related to its effect on phosphatidylinositol metabolism.

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The anti-proliferative effect of lithium chloride on melanoma cells and its reversion by myo-inositol

Abstract

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