The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community

Lindsay G. Cowell; Scott Christley; Felix Breden; Kevin A. Burns; Brian D. Corrie; William D. Lees; James A. Overton; Bjoern Peters; Eve Richardson; Krishna M. Roskin; Lonneke Scheffer; Randi Vita; Corey T. Watson; Gur Yaari

doi:10.1016/j.cels.2025.101401

The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community

Lindsay G. Cowell
, Scott Christley
, Felix Breden
, Kevin A. Burns
, Brian D. Corrie
, William D. Lees
, James A. Overton
, Bjoern Peters
, Eve Richardson
, Krishna M. Roskin
, Lonneke Scheffer
, Randi Vita
, Corey T. Watson
, Gur Yaari

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Sequencing data elucidating adaptive immune receptor (AIR) repertoires, genomic loci encoding AIR genes, and AIR antigens are hosted in siloed repositories, limiting integrative analyses. We are in the process of creating the AIR Repertoire Knowledge Commons (AKC) by merging data from community-backed repositories and applying knowledge-generation algorithms to integrate and enrich data and metadata.

Original language	English
Article number	101401
Journal	Cell Systems
Volume	16
Issue number	9
DOIs	https://doi.org/10.1016/j.cels.2025.101401
State	Published - 17 Sep 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2025 Elsevier Inc.

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10.1016/j.cels.2025.101401

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Cowell, L. G., Christley, S., Breden, F., Burns, K. A., Corrie, B. D., Lees, W. D., Overton, J. A., Peters, B., Richardson, E., Roskin, K. M., Scheffer, L., Vita, R., Watson, C. T., & Yaari, G. (2025). The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community. Cell Systems, 16(9), Article 101401. https://doi.org/10.1016/j.cels.2025.101401

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abstract = "Sequencing data elucidating adaptive immune receptor (AIR) repertoires, genomic loci encoding AIR genes, and AIR antigens are hosted in siloed repositories, limiting integrative analyses. We are in the process of creating the AIR Repertoire Knowledge Commons (AKC) by merging data from community-backed repositories and applying knowledge-generation algorithms to integrate and enrich data and metadata.",

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note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

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doi = "10.1016/j.cels.2025.101401",

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AU - Christley, Scott

AU - Breden, Felix

AU - Burns, Kevin A.

AU - Corrie, Brian D.

AU - Lees, William D.

AU - Overton, James A.

AU - Peters, Bjoern

AU - Richardson, Eve

AU - Roskin, Krishna M.

AU - Scheffer, Lonneke

AU - Vita, Randi

AU - Watson, Corey T.

AU - Yaari, Gur

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The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community

Abstract

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