Testosterone in ancient hair from an extinct species

Lee Koren, Devorah Matas, Patrícia Pečnerová, Love Dalén, Alexei Tikhonov, M. Thomas P. Gilbert, Katherine E. Wynne-Edwards, Eli Geffen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Testosterone is a key regulator in vertebrate development, physiology and behaviour. Whereas technology allows extraction of a wealth of genetic information from extant as well as extinct species, complementary information on steroid hormone levels may add a social, sexual and environmental context. Hair shafts have been previously used to sequence DNA from >50 000 14C years old Siberian woolly mammoths (Mammuthus primigenius). Hair-testing has also been used to measure endogenous steroids in multiple extant species. Here we use small quantities of woolly mammoth hair samples to measure testosterone, and a genomics-based approach to determine sex, in permafrost-preserved mammoths dated to c. 10 000–60 000 14C years. Our validated method opens up exciting opportunities to measure multiple steroids in keratinized tissues from extinct populations of mammals. This may be specifically applied to investigating life histories, including the extinct Quaternary megafauna populations whose remains are preserved in the permafrost throughout the northern hemisphere.

Original languageEnglish
Pages (from-to)797-802
Number of pages6
JournalPalaeontology
Volume61
Issue number6
Early online date13 Aug 2018
DOIs
StatePublished - Nov 2018

Bibliographical note

Publisher Copyright:
© The Palaeontological Association

Keywords

  • endogenous steroids
  • hair-testing
  • testosterone
  • woolly mammoth

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