Testosterone deficiency and the metabolic syndrome

Bruno Lunenfeld

    Research output: Contribution to journalArticlepeer-review

    22 Scopus citations


    Evidence is presented to link components of the metabolic syndrome to testosterone deficiency and obesity. Testosterone deficiency in hypogonadism or testosterone deprivation in normo-gonadotropic men increases fat mass as well as fasting insulin levels. Testosterone supplementation (TS) in a dose dependent manner, increase lean body mass (LBM), reduces fat mass, body mass index (BMI) and waist hip ratio in both young and elderly hypogonadal men. A negative association between T and insulin resistance as well as impaired glucose intolerance has been demonstrated and in type 2 diabetic men TS improves metabolic parameters. TS improves most components of the metabolic syndrome and also reduces inflammatory cytokines.

    Original languageEnglish
    Pages (from-to)53-56
    Number of pages4
    JournalAging Male
    Issue number2
    StatePublished - Jun 2007


    • Diabetes hypogonadism
    • Metabolic syndrome
    • Obesity
    • Testosterone deprivation


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