Testosterone deficiency accompanied by testicular and epididymal abnormalities in TMF-/- mice

Yoav Elkis, Shai Bel, Tali Lerer-Goldstein, Abraham Nyska, Dianne M. Creasy, Sally Shpungin, Uri Nir

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

TMF/ARA160 is a Golgi-associated protein, which is essential for spermiogenesis. In this study, we show that lack of TMF/ARA160 leads to defects in both the testis and the epididymis. In the testis, spermatid retention and extensive proliferation of Leydig cells were observed. Concomitantly, the serum levels of luteinizing hormone (LH), a stimulator of Leydig cell proliferation, were significantly increased in TMF-/- mice. Structural and functional defects were also seen in the epididymis. These included apoptosis of epithelial epididymal cells and sperm stasis in the cauda. Notably, the serum testosterone levels of TMF-/- mice were significantly lower than those of wt mice, and external testosterone administration decreased the number of apoptotic epithelial epididymal cells in TMF-/- animals. In summary, we show here for the first time that TMF/ARA160 participates in the control of serum testosterone levels in males, and its absence results in major testicular and epididymal defects.

Original languageEnglish
Pages (from-to)52-63
Number of pages12
JournalMolecular and Cellular Endocrinology
Volume365
Issue number1
DOIs
StatePublished - 5 Jan 2013

Bibliographical note

Funding Information:
This work was supported by a grant from the Ihel Foundation.

Keywords

  • Androgen
  • Apoptosis
  • Epididymis
  • LH
  • TMF/ARA160
  • Testis

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