Ternary DNA computing using 3 x 3 multiplication matrices

Ron Orbach, Sivan Lilienthal, Michael Klein, R. D. Levine, Francoise Remacle, Itamar Willner

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Non-Boolean computations implementing operations on multi-valued variables beyond base 2 allow enhanced computational complexity. We introduce DNA as a functional material for ternary computing, and in particular demonstrate the use of three-valued oligonucleotide inputs to construct a 3 x 3 multiplication table. The system consists of two three-valued inputs of -1; 0; +1 and a fluorophore/quencher functional hairpin acting as computational and reporter module. The interaction of the computational hairpin module with the different values of the inputs yields a 3 x 3 multiplication matrix consisting of nine nanostructures that are read out by three distinct fluorescence intensities. By combining three different hairpin computational modules, each modified with a different fluorophore/quencher pair, and using different sets of inputs, the parallel operation of three multiplication tables is demonstrated.

Original languageEnglish
Pages (from-to)1288-1292
Number of pages5
JournalChemical Science
Issue number2
StatePublished - 1 Feb 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.


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