TY - JOUR
T1 - Temperature and humidity modify airway response to inhaled histamine in normal subjects
AU - Amirav, I.
AU - Plit, M.
PY - 1989/11
Y1 - 1989/11
N2 - The airway response to inhaled histamine is known to be influenced by various stimuli (e.g., infection, ozone). Temperature (T) has been shown to affect it in vitro. We studied whether T and humidity (H) modify airway response to inhaled histamine in normal subjects. Twelve normal subjects 21 to 46 yr of age (mean age, 29 yr) performed two similar histamine inhalation tests, the only difference being the conditions of the inspired air. One test was done while breathing cold dry air (mean T ± SEM, -17.3 ± 1.8°C; relative H, 0%) and the other while breathing warm humid air (mean T ± SEM, 33.9 ± 0.5°C; relative H, 100%). Whereas the geometric mean histamine concentration required to produce a 15% fall in FEV1 in the warm humid tests was 22.7 mg/ml, it was 11.9 mg/ml in the cold dry test (p < 0.01). It is concluded that the T and H of inspired air modify the airway response to inhaled histamine in normal subjects.
AB - The airway response to inhaled histamine is known to be influenced by various stimuli (e.g., infection, ozone). Temperature (T) has been shown to affect it in vitro. We studied whether T and humidity (H) modify airway response to inhaled histamine in normal subjects. Twelve normal subjects 21 to 46 yr of age (mean age, 29 yr) performed two similar histamine inhalation tests, the only difference being the conditions of the inspired air. One test was done while breathing cold dry air (mean T ± SEM, -17.3 ± 1.8°C; relative H, 0%) and the other while breathing warm humid air (mean T ± SEM, 33.9 ± 0.5°C; relative H, 100%). Whereas the geometric mean histamine concentration required to produce a 15% fall in FEV1 in the warm humid tests was 22.7 mg/ml, it was 11.9 mg/ml in the cold dry test (p < 0.01). It is concluded that the T and H of inspired air modify the airway response to inhaled histamine in normal subjects.
UR - http://www.scopus.com/inward/record.url?scp=0024441673&partnerID=8YFLogxK
U2 - 10.1164/ajrccm/140.5.1416
DO - 10.1164/ajrccm/140.5.1416
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C2 - 2817605
AN - SCOPUS:0024441673
SN - 0003-0805
VL - 140
SP - 1416
EP - 1420
JO - American Review of Respiratory Disease
JF - American Review of Respiratory Disease
IS - 5
ER -