@article{0d9833c397f84836bb198801406c0684,
title = "TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription",
abstract = "The RNA polymerase II core promoter is a structurally and functionally diverse transcriptional module. RNAi depletion and overexpression experiments revealed a genetic circuit that controls the balance of transcription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE). In this circuit, TBP activates TATA-dependent transcription and represses DPE-dependent transcription, whereas Mot1 and NC2 block TBP function and thus repress TATA-dependent transcription and activate DPE-dependent transcription. This regulatory circuit is likely to be one means by which biological networks can transmit transcriptional signals, such as those from DPE-specific and TATA-specific enhancers, via distinct pathways.",
keywords = "Core promoter, Mot1, NC2, RNA polymerase II, TBP, Transcription",
author = "Hsu, {Jer Yuan} and Tamar Juven-Gershon and Marr, {Michael T.} and Wright, {Kevin J.} and Robert Tjian and Kadonaga, {James T.}",
year = "2008",
month = sep,
day = "1",
doi = "10.1101/gad.1681808",
language = "אנגלית",
volume = "22",
pages = "2353--2358",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "17",
}