Abstract
The RNA polymerase II core promoter is a structurally and functionally diverse transcriptional module. RNAi depletion and overexpression experiments revealed a genetic circuit that controls the balance of transcription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE). In this circuit, TBP activates TATA-dependent transcription and represses DPE-dependent transcription, whereas Mot1 and NC2 block TBP function and thus repress TATA-dependent transcription and activate DPE-dependent transcription. This regulatory circuit is likely to be one means by which biological networks can transmit transcriptional signals, such as those from DPE-specific and TATA-specific enhancers, via distinct pathways.
Original language | English |
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Pages (from-to) | 2353-2358 |
Number of pages | 6 |
Journal | Genes and Development |
Volume | 22 |
Issue number | 17 |
DOIs | |
State | Published - 2 Sep 2008 |
Externally published | Yes |
Keywords
- Core promoter
- Mot1
- NC2
- RNA polymerase II
- TBP
- Transcription