Targeted regulation of nuclear lamins by ubiquitin and ubiquitin-like modifiers

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5 Scopus citations

Abstract

Nuclear lamins (NLs) are essential components of the animal cell nucleus involved in the regulation of a plethora of molecular and cellular processes. These include the nuclear envelope assembly and stability, mechanotransduction and chromatin organization, transcription, DNA replication, damage repair, and genomic integrity maintenance. Mutations in NLs can lead to the development of a wide range of distinct disease phenotypes, laminopathies, consisting of cardiac, neuromuscular, metabolic and premature aging syndromes. In addition, alterations in the expression of nuclear lamins were associated with different types of neoplastic diseases. Despite the importance and critical roles that NLs play in the diverse cellular activities, we only recently started to uncover the complexity of regulatory mechanisms governing their expression, localization and functions. This integrative review summarizes and discusses the recent findings on the emerging roles of ubiquitin and ubiquitin-like modifiers (ULMs) in the regulation of NLs, highlighting the intriguing molecular associations and cross-talks occurring between NLs and these regulatory molecules under physiological conditions and in the disease states.

Original languageEnglish
Article number1335
JournalCells
Volume9
Issue number6
DOIs
StatePublished - 27 May 2020

Bibliographical note

I am grateful to Dayan Family Foundation for their continued support of our research, as well as to the Israel Cancer Association (#20200007) and the Roland and Dawn Arnall Foundation.

Keywords

  • Autophagy
  • Laminopathies
  • Nuclear lamins
  • Proteasome
  • Ubiquitin
  • Ubiquitin-like modifiers

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