TY - JOUR
T1 - Targeted disruption of mouse EGF receptor
T2 - Effect of genetic background on mutant phenotype
AU - Threadgill, David W.
AU - Dlugosz, Andrzej A.
AU - Hansen, Laura A.
AU - Tennenbaum, Tamar
AU - Lichti, Ulrike
AU - Yee, Della
AU - LaMantia, Christian
AU - Mourton, Tracy
AU - Herrup, Karl
AU - Harris, Raymond C.
AU - Barnard, John A.
AU - Yuspa, Stuart H.
AU - Coffey, Robert J.
AU - Magnuson, Terry
PY - 1995
Y1 - 1995
N2 - Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.
AB - Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.
UR - https://www.scopus.com/pages/publications/0029064203
U2 - 10.1126/science.7618084
DO - 10.1126/science.7618084
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C2 - 7618084
AN - SCOPUS:0029064203
SN - 0036-8075
VL - 269
SP - 230
EP - 234
JO - Science
JF - Science
IS - 5221
ER -