Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer

I. Rosenberger, A. Strauss, S. Dobiasch, C. Weis, S. Szanyi, L. Gil-Iceta, E. Alonso, M. González Esparza, V. Gómez-Vallejo, B. Szczupak, S. Plaza-García, S. Mirzaei, L. L. Israel, S. Bianchessi, E. Scanziani, J. P. Lellouche, P. Knoll, J. Werner, K. Felix, L. GrenacherT. Reese, J. Kreuter, M. Jiménez-González

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Abstract Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6 months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, γ-Fe2O3) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography-computer tomography (SPECT-CT), a handheld gamma camera, and magnetic resonance imaging (MRI).

Original languageEnglish
Article number7764
Pages (from-to)76-84
Number of pages9
JournalJournal of Controlled Release
Volume214
DOIs
StatePublished - 28 Sep 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

  • Handheld gamma camera
  • Maghemite
  • Magnetic resonance imaging (MRI)
  • Single photon emission computed tomography-computer tomography (SPECT-CT)
  • rHSA nanoparticles
  • t-PA-ligands to galectins
  • t-PApeptide1<inf>LAC</inf>

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