Takotsubo Syndrome in the Emergency Room — Diagnostic Challenges and Suggested Algorithm

Gassan Moady, Gal Rubinstein, Loai Mobarki, Shaul Atar

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Takotsubo syndrome is an important condition to consider among patients with acute chest pain in the emergency room. It often mimics acute coronary syndrome since chest pain and ECG changes are key features in both conditions. The hallmark of takotsubo syndrome is transient left ventricular dysfunction (characterized by apical ballooning) followed by complete echocardiographic recovery in most cases. Although most patients exhibit a benign course, lethal complications may occur. The use of hand-held point-of-care focused cardiac ultrasound may be helpful for early identification of takotsubo syndrome and distinguishing it from acute coronary syndrome and other cardiovascular emergencies. Emergency room physicians should be familiar with typical and atypical presentations of takotsubo syndrome and its key electrocardiographic changes. The approach in the emergency room should be based on a combination the clinical presentation, ECG, and handheld echocardiography device findings, rather than a single electrocardiographic algorithm.

Original languageEnglish
Article number131
JournalReviews in Cardiovascular Medicine
Issue number4
StatePublished - 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s).


  • acute coronary syndrome
  • echocardiography
  • point-of-care focused cardiac ultrasound
  • takotsubo syndrome


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