Tables of the number of patients required in clinical trials using the logrank test

L. S. Freedman

Research output: Contribution to journalArticlepeer-review

574 Scopus citations

Abstract

The logrank test is commonly used in the analysis of clinical trials in chronic diseases such as cancer. Existing tables for the number of patients required in such trials are based on the direct comparison of two proportions. This paper presents tables of numbers required in clinical trials using the logrank test and describes their use. The numbers required are considerably smaller than those in existing tables when the event‐free proportions are small, but otherwise comparable.

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalStatistics in Medicine
Volume1
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

Keywords

  • Clinical trials
  • Logrank test
  • Power

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