T cell differentiation: A mechanistic view

Orly Avni, Anjana Rao

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


It has recently become clear that cytokine expression by T cells involves epigenetic changes in chromatin structure, locus accessibility and DNA methylation that occur during differentiation of naive T cells into mature effector T cells. These changes require the coordinate actions of antigen- and cytokine-induced transcription factors, chromatin remodeling complexes, histone-modifying enzymes and subset-specific transcription factors.

Original languageEnglish
Pages (from-to)654-659
Number of pages6
JournalCurrent Opinion in Immunology
Issue number6
StatePublished - 2000
Externally publishedYes

Bibliographical note

Funding Information:
We apologise to all those whose work we could not cite because of space limitations. We thank S Agarwal for the original version of Fig. 1 (adapted from his PhD thesis, Harvard University) and D Lee, C Lopez-Rodriguez, S Feske and other members of the laboratory for helpful discussions. This work was supported by National Institutes of Health grants CA42471 and AI44432 (to AR). OA is supported by a postdoctoral fellowship from the Cancer Research Institute.


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