Systemic and disease-specific risk factors in vascular dementia: Diagnosis and prevention

Efraim Jaul, Oded Meiron

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


In order to prevent the onset of vascular dementia (VaD) in aging individuals, it is critical to detect clinically relevant vascular and systemic pathophysiological changes to signal the onset of its preceding prodromal stages. Identifying behavioral and neurobiological markers that are highly sensitive to VaD classification vs. other dementias is likely to assist in developing novel preventive treatment strategies that could delay the onset of disruptive psychomotor symptoms, decrease hospitalizations, and increase the quality of life in clinically-high-risk aging individuals. In light of empirical diagnostic and clinical findings associated with VaD pathophysiology, the current investigation will suggest a few clinically-validated biomarker measures of prodromal VaD cognitive impairments that are correlated with vascular symptomology, and VaD endophenotypes in non-demented aging people. In prodromal VaD individuals, distinguishing VaD from other dementias (e.g., Alzheimer's disease) could facilitate specific early preventive interventions that significantly delay more severe cognitive deterioration or indirectly suppress the onset of dementia with vascular etiology. Importantly, the authors conclude that primary prevention strategies should examine aging individuals by employing comprehensive geriatric assessment approach, taking into account their medical history, and longitudinally noting their vascular, systemic, cognitive, behavioral, and clinical functional status. Secondary prevention strategies may include monitoring chronic medication as well as promoting programs that facilitate social interaction and every-day activities.

Original languageEnglish
Article number333
JournalFrontiers in Aging Neuroscience
Issue numberOCT
StatePublished - 17 Oct 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Jaul and Meiron. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).


  • Cerebrovascular risk factors
  • Comprehensive geriatric assessment
  • Prevention
  • Prodromal stage
  • Vascular cognitive impairment


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