Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity

Samuel Braverman; Marina Cherkinsky; Yulia Kalendar; Ranjan Jana; Milon Sprecher; Israel Goldberg

doi:10.1055/s-0033-1338555

Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity

Samuel Braverman, Marina Cherkinsky, Yulia Kalendar, Ranjan Jana, Milon Sprecher, Israel Goldberg

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

A convenient procedure for the synthesis of novel bis-(1-hydroxymethyl-2- halo-3-hydroxy-1-propylene) selenides has been developed. On oxidation these compounds form novel seleno-spiro compounds and their glutathione peroxidase mimetic activity has been studied. They promote the hydrogen peroxide oxidation of phenylmethanethiol to the corresponding disulfide via a catalytic cycle.

Original language	English
Article number	SS-2013-Z0588-OP
Pages (from-to)	119-125
Number of pages	7
Journal	Synthesis (Germany)
Volume	46
Issue number	1
DOIs	https://doi.org/10.1055/s-0033-1338555
State	Published - 2 Jan 2014

Keywords

alkynes
diols
oxidation
selenium
spiro compounds

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10.1055/s-0033-1338555

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abstract = "A convenient procedure for the synthesis of novel bis-(1-hydroxymethyl-2- halo-3-hydroxy-1-propylene) selenides has been developed. On oxidation these compounds form novel seleno-spiro compounds and their glutathione peroxidase mimetic activity has been studied. They promote the hydrogen peroxide oxidation of phenylmethanethiol to the corresponding disulfide via a catalytic cycle.",

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AU - Kalendar, Yulia

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AU - Sprecher, Milon

AU - Goldberg, Israel

PY - 2014/1/2

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AB - A convenient procedure for the synthesis of novel bis-(1-hydroxymethyl-2- halo-3-hydroxy-1-propylene) selenides has been developed. On oxidation these compounds form novel seleno-spiro compounds and their glutathione peroxidase mimetic activity has been studied. They promote the hydrogen peroxide oxidation of phenylmethanethiol to the corresponding disulfide via a catalytic cycle.

KW - alkynes

KW - diols

KW - oxidation

KW - selenium

KW - spiro compounds

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ER -

Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity

Abstract

Keywords

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