Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity

Samuel Braverman; Marina Cherkinsky; Yulia Kalendar; Ranjan Jana; Milon Sprecher; Israel Goldberg

doi:10.1055/s-0033-1338555

Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity

Samuel Braverman, Marina Cherkinsky, Yulia Kalendar, Ranjan Jana, Milon Sprecher, Israel Goldberg

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

A convenient procedure for the synthesis of novel bis-(1-hydroxymethyl-2- halo-3-hydroxy-1-propylene) selenides has been developed. On oxidation these compounds form novel seleno-spiro compounds and their glutathione peroxidase mimetic activity has been studied. They promote the hydrogen peroxide oxidation of phenylmethanethiol to the corresponding disulfide via a catalytic cycle.

Original language	English
Article number	SS-2013-Z0588-OP
Pages (from-to)	119-125
Number of pages	7
Journal	Synthesis (Germany)
Volume	46
Issue number	1
DOIs	https://doi.org/10.1055/s-0033-1338555
State	Published - 2 Jan 2014

Keywords

alkynes
diols
oxidation
selenium
spiro compounds

Access to Document

10.1055/s-0033-1338555

Cite this

@article{cb771846ba30457cb44130e1346e6d78,

title = "Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity",

abstract = "A convenient procedure for the synthesis of novel bis-(1-hydroxymethyl-2- halo-3-hydroxy-1-propylene) selenides has been developed. On oxidation these compounds form novel seleno-spiro compounds and their glutathione peroxidase mimetic activity has been studied. They promote the hydrogen peroxide oxidation of phenylmethanethiol to the corresponding disulfide via a catalytic cycle.",

keywords = "alkynes, diols, oxidation, selenium, spiro compounds",

author = "Samuel Braverman and Marina Cherkinsky and Yulia Kalendar and Ranjan Jana and Milon Sprecher and Israel Goldberg",

year = "2014",

month = jan,

day = "2",

doi = "10.1055/s-0033-1338555",

language = "אנגלית",

volume = "46",

pages = "119--125",

journal = "Synthesis (Germany)",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

number = "1",

}

TY - JOUR

T1 - Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity

AU - Braverman, Samuel

AU - Cherkinsky, Marina

AU - Kalendar, Yulia

AU - Jana, Ranjan

AU - Sprecher, Milon

AU - Goldberg, Israel

PY - 2014/1/2

Y1 - 2014/1/2

N2 - A convenient procedure for the synthesis of novel bis-(1-hydroxymethyl-2- halo-3-hydroxy-1-propylene) selenides has been developed. On oxidation these compounds form novel seleno-spiro compounds and their glutathione peroxidase mimetic activity has been studied. They promote the hydrogen peroxide oxidation of phenylmethanethiol to the corresponding disulfide via a catalytic cycle.

AB - A convenient procedure for the synthesis of novel bis-(1-hydroxymethyl-2- halo-3-hydroxy-1-propylene) selenides has been developed. On oxidation these compounds form novel seleno-spiro compounds and their glutathione peroxidase mimetic activity has been studied. They promote the hydrogen peroxide oxidation of phenylmethanethiol to the corresponding disulfide via a catalytic cycle.

KW - alkynes

KW - diols

KW - oxidation

KW - selenium

KW - spiro compounds

UR - http://www.scopus.com/inward/record.url?scp=84890562756&partnerID=8YFLogxK

U2 - 10.1055/s-0033-1338555

DO - 10.1055/s-0033-1338555

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:84890562756

SN - 0039-7881

VL - 46

SP - 119

EP - 125

JO - Synthesis (Germany)

JF - Synthesis (Germany)

IS - 1

M1 - SS-2013-Z0588-OP

ER -

Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this